Advanced Science, EarlyView.This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao +6 more
wiley +1 more source
Innovative colorimetric thermal study of methylcellulose hydrogel via smartphone imaging. [PDF]
Sci RepDanieli I, Rittel D.
europepmc +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Ascitic fluid analysis in acute pancreatitis: Clinically promising but methodologically constrained prognostic indicators. [PDF]
World J GastroenterolLee YC, Chon HK.
europepmc +1 more source
Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis
Advanced Science, EarlyView.By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao +7 more
wiley +1 more source
Solid Phase Extraction and Determination of Tetracycline Using Gold Nanoparticles Stabilized in a Polymethacrylate Matrix. [PDF]
MoleculesSaranchina NV +3 more
europepmc +1 more source
Advanced Science, EarlyView.A triple‐mode theranostic platform enables integrated electrochemical, colorimetric, and photothermal detection of bacterial infection. Glucose oxidation triggers H2O2 generation and TMB oxidation to oxTMB, producing color and thermal signals under 808 nm NIR irradiation.
Jing Xu +8 more
wiley +1 more source
Green and simple microextraction method based on deep eutectic solvent-assisted smartphone digital imaging colorimetry (SDIC) for Rhodamine B analysis in food products. [PDF]
Anal Bioanal ChemTezcan B, Dalmaz A, Sivrikaya Özak S.
europepmc +1 more source
Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
Advanced Science, EarlyView.We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
Tailored Catalytic Microenvironments Enable Efficient Electrochemical Ammonia Production
Advanced Science, EarlyView.This study shows that Co2+ substitution in inverse spinel FeFeCoO4 constructs an integrated catalytic microenvironment for efficient nitrate‐to‐ammonia reduction. Jahn–Teller distortion activates Fe sites for *H generation, while hard–soft acid–base regulated dual‐metal sites optimize proton‐coupled electron transfer and intermediate adsorption ...
Qi Zhang +8 more
wiley +1 more source