Results 211 to 220 of about 30,569 (272)

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Icaritin inhibits breast cancer through activating MT1X to promote ferroptosis and synergizing with NF-κB pathway suppression. [PDF]

Front Oncol
Zhan F, Qiu D, Wang C, Sun N.
europepmc   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Nanozymatic platform for dual colorimetric and fluorimetric sensing of H₂O₂ and glucose using Ni-CoWO₄ nanoparticles. [PDF]

Sci Rep
Asl KJ, Naseri A, Amjadi M, Alavi SMS, Pariz A, Tatardar F, Rasoulzadeh F.   +6 more
europepmc   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

Fast, easy and green method for the first quantification of niacinamide in serums and creams by digital image analysis using iron (III) chloride. [PDF]

Mikrochim Acta
Lambarri A, Ostra M, Bordagaray A, Garcia-Arrona R, Vidal M.   +4 more
europepmc   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Radiation-Sensitive Thin Film Dosimeter Based on Polyvinyl Alcohol (PVA)/Hafnium Dioxide (HfO₂)/Silver Nitrate (AgNO₃) Composite: Colorimetric Characterization and Dose-Response Analysis for Low-Dose Gamma-Ray Applications. [PDF]

Polymers (Basel)
Alashrah S.
europepmc   +1 more source

Food characterization in the omics era: current advances, analytical approaches, and future perspectives. [PDF]

Front Nutr
Ibrahim MS, Azeem W, Sakandar HA, Curran D, Yousaf AA, Zabetakis I.   +5 more
europepmc   +1 more source

Challenges in colorimetric evaluation of femtosecond laser cleaning on historical leather: influence of surface porosity and microstructure. [PDF]

NPJ Herit Sci
Boynukara CY, Welsch ML, Zanotto L, Caron L, Uguryol M, Mavili G, Razzari L, Muehlethaler C, Ruediger A, Antici P.   +9 more
europepmc   +1 more source