Results 261 to 270 of about 64,372 (396)

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

open access: yesAdvanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li   +9 more
wiley   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

open access: yesAdvanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong   +18 more
wiley   +1 more source

Establishment and evaluation of a method for measuring ornithine transcarbamylase activity in micro blood of neonates. [PDF]

open access: yesOrphanet J Rare Dis
Zhang Z   +9 more
europepmc   +1 more source

Speciation analysis based on digital image colorimetry: Iron (II/III) in white wine.

open access: yesTalanta: The International Journal of Pure and Applied Analytical Chemistry, 2019
Joao H. Santos Neto   +5 more
semanticscholar   +1 more source

Releasing 8.0 wt.% H2 from the LiBH4−2LiNH2 Composite within 5 Min under Light Illumination

open access: yesAdvanced Science, EarlyView.
The N−H bond in the [NH2]− ion group is significantly weakened by the non‐thermal effect of UV light, leading to a 60‐fold increase in dehydrogenation rate at the same temperature. As a result, over 8.0 wt.% H2 is released within 5 min. Abstract The absence of safe and efficient hydrogen storage technologies is the major bottleneck for widespread ...
Haoyang Yu   +7 more
wiley   +1 more source

Field Determination of Leachable Chromium(VI) in Soil by Ultrasonic Extraction-Diphenylcarbazide Colorimetry

open access: bronze, 2007
Susumu Kawakubo   +4 more
openalex   +2 more sources

Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression

open access: yesAdvanced Science, EarlyView.
GLed, a reversible lanthanide‐based GSH sensor that enables real‐time, single‐cell measurement of Gamma–Glutamyl Cysteine Ligase (GCL) activity ‐whose role in human T cells remains unclear‐ is developed. GLed directly links GCL activity to T cell effector functions and reveals its modulation by immunosuppressive drugs, identifying GCL as a critical ...
Francisco Fueyo‐González   +9 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao   +8 more
wiley   +1 more source

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