Results 71 to 80 of about 262,925 (314)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Drug-induced hair colour changes [PDF]

, 2016
Hair colour modifications comprise lightening/graying, darkening, or even a complete hair colour change, which may involve the scalp and/or all body hair. Systemic medications may cause hair loss or hypertrichosis, while hair colour change is an uncommon
De Simone, Clara, Del Regno, Laura, Ricci, Francesco, Peris, Ketty   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

An ex vivo comparison study: the effect of a fatty acid ester and a cationic silicone derivative on the protection of hair colour from washing and heat styling exposure [PDF]

, 2014
The hair colour market is a major player within the hair care industry. Hair colour protection from shampoo related fading is becoming a popular claim on shampoos.
Grant-Ross, Peter, Arendes, Brita, Tamburic, Slobodanka, Labedzka, Maria, Varcin, Mustafa   +4 more
core  

Changes in women's facial skin color over the ovulatory cycle are not detectable by the human visual system [PDF]

, 2015
RPB is supported by an Anniversary Research Fellowship at Northumbria University. MS and JT were supported by a David Philips Research Fellowship awarded to MS by the Biological Sciences Research Council (BBSRC) (BB/G022887/1).
Quigley, R., Saxton, Tamsin, Stevens, M., Robert P. Burriss (764579), Payne, J., Anthony J C Fulford, Robert P Burriss, Jenny Payne (764582), Lovell, P., Rowland, H., Martin Stevens, Burriss, Robert, P. George Lovell (764580), Rowland, Hannah M., Burriss, R., Lovell, P George, Jenny Payne, Fulford, Anthony JC, Saxton, Tamsin K, Martin Stevens (456599), Payne, Jenny, Jolyon Troscianko (456596), Troscianko, Jolyon, Jolyon Troscianko, Fulford, Anthony, Lovell, P. George, Burriss, Robert P, Hannah M. Rowland (764584), Stevens, Martin, Quigley, Rachael, Troscianko, J., Rowland, Hannah M, Rachael Quigley (764581), Fulford, Anthony J. C., Saxton, Tamsin K., Rachael Quigley, Rowland, Hannah, Tamsin K. Saxton (764583), Anthony J. C. Fulford (241917), Fulford, A., P George Lovell, Tamsin K Saxton, Lovell, P. George; id_orcid, Saxton, T., Burriss, Robert P., Hannah M Rowland   +45 more
core   +1 more source

Chromatic illumination discrimination ability reveals that human colour constancy is optimised for blue daylight illuminations.

PLoS ONE, 2014
The phenomenon of colour constancy in human visual perception keeps surface colours constant, despite changes in their reflected light due to changing illumination.
Bradley Pearce, Stuart Crichton, Michal Mackiewicz, Graham D Finlayson, Anya Hurlbert   +4 more
doaj   +1 more source

Dynamic colour change as a signalling tool in bluelined goatfish (Upeneicthtys lineatus)

Ecology and Evolution, 2023
Many animal species can rapidly change their body colouration and patterning, but often the ecological drivers of such changes are unknown. Here, we explored dynamic colour change in the bluelined goatfish, Upeneichthys lineatus, a temperate marine ...
Louise Tosetto, Nathan S. Hart, Jane E. Williamson   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The effect of natural weathering on untreated wood surface

Maderas: Ciencia y Tecnología, 2017
As a result of contemporary ecological and sustainable movements, a number of constructions from wood, as the only renewable building material, is still increasing. In accordance with these trends, wood elements are often left untreated.
Eliška Oberhofnerová, Miloš Pánek, Alba García-Cimarras   +2 more
doaj