Results 61 to 70 of about 613,537 (264)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Optimal learning spaces: design implications for primary schools [PDF]

, 2009
Review guide of the design evidence for primary ...
Barrett, PS, Zhang, Y
core  

Contemporary artists and colour: meaning, organisation and understanding [PDF]

, 2005
What implications do the ranges of traditional and non-traditional media used by contemporary artists have for understanding the selection and specification of coloured materials?
Batchelor, Danto, Gillick, Hardin, Judith Mottram, Riley, Saunders   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The structure of spiral galaxies: radial profiles in stellar Mass-to-Light ratio and the Dark Matter distribution [PDF]

, 2010
The colour and metallicity gradients observed in spiral galaxies suggest that the mass-to-light ratio (M*/L) of the stellar disc is a function of radius. This is indeed predicted by chemo-photometric models of galactic discs.
Ashman, Bakos, Bell, Bell, Bell, Boissier, Boissier, Boissier, Burkert, Burkert, Chabrier, Chabrier, Chiappini, Chiappini, de Blok, de Blok, de Jong, de Jong, de Jong, de Jong, Dopita, Flynn, Freeman, Garnett, Gentile, Gentile, Gummersbach, Jansen, Kassin, Kennicutt, Kennicutt, Kent, Kranz, Kroupa, Kuzio de Naray, L. Portinari, Larson, Larson, Lynden-Bell, López-Corredoira, Martin, Matteucci, Mollá, Mollá, Mollá, Navarro, Navarro, P. Salucci, Persic, Persic, Portinari, Portinari, Portinari, Portinari, Prantzos, Renda, Roberts, Roskar, Ryder, Salpeter, Salucci, Salucci, Salucci, Salucci, Sanders, Schönrich, Shaver, Smartt, Sommer-Larsen, Sommer-Larsen, Spano, Spekkens, Treuthardt, van Zee   +73 more
core   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

On the relation between Seyfert 2 accretion rate and environment at z < 0.1 [PDF]

, 2014
We analyse different properties of the small-scale environment of Seyfert 2 for two samples selected according to the accretion rate parameter, R, from the Sloan Digital Sky Survey, Data Release 7 survey.
Coldwell Lloveras, Georgina Vanesa, Diaz Tello, Jorge Andres, Garcia Lambas, Diego Rodolfo, Gurovich, Sebastian, Söchting, Ilona K.   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The New Technology for In Vitro Culture with Induction of Nanobubbles (NBsN2 and NBsO2) in Cattleya sp.

Biology, Medicine & Natural Product Chemistry
The growth and development of orchids take a relatively long time, while the demand for high-quality orchids continues to increase significantly. Tissue culture is a technique of isolating plant parts in organs, tissues, and cells and then culturing ...
Moch Mustakim, Azis Mawardi, Lina Purnama Dewi, Nela Vede Rhofa Putri, Tintrim Rahayu, Gatra Ervi Jayanti   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source