Results 101 to 110 of about 1,071,876 (307)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Harnessing graphene oxide-enhanced composite metal-organic frameworks for efficient wastewater treatment

Water Cycle
The issue of carwash wastewater emerges as a pressing environmental concern on a global scale, primarily due to the intricate nature of its pollutants, which makes effective treatment a formidable challenge.
Timoth Mkilima, Yerkebulan Zharkenov, Laura Utepbergenova, Aisulu Abduova, Nursulu Sarypbekova, Elmira Smagulova, Gulnara Abdukalikova, Fazylov Kamidulla, Iliyas Zhumadilov   +8 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Study on Collapse Resistance of RC Frame under the Corner Column Removal Scenario. [PDF]

Materials (Basel), 2021
Xu J, Wang S, Liu K, Quan X, Dong F.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Iron crosslinked alginate as novel nanosorbents for removal of arsenic ions and bacteriological contamination from water

Journal of Materials Research and Technology, 2014
Fixed-bed column studies were conducted to evaluate performance of Fe (III) crosslinked alginate nanoparticles for the removal of pentavalent arsenic ions [As (V)] from aqueous environments. The study involved observing the influences of column bed depth,
Priyanka Singh, Sunil Kumar Singh, Jaya Bajpai, Anil Kumar Bajpai, Ravi Bahadur Shrivastava   +4 more
doaj   +1 more source

A model study of enhanced oil recovery by flooding with aqueous surfactant solution and comparison with theory [PDF]

, 2015
With the aim of elucidating the details of enhanced oil recovery by surfactant solution flooding, we have determined the detailed behavior of model systems consisting of a packed column of calcium carbonate particles as the porous rock, n-decane as the ...
Clarke, Andrew, Fletcher, Paul D. I., Howe, Andrew M., Savory, Luke D., Woods, Freya   +4 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dynamic Response Analysis of Infilled RC Frames with Openings Under Instantaneous Column Removal Scenarios

Buildings
In order to further explore the role of infill walls in the progressive collapse resistance of reinforced concrete (RC) spatial frames, based on ANSYS/LS-DYNA finite element analysis software, the refined numerical models of pure RC spatial frames and ...
Jia-Liang Wang, Yu Zou, Huan Liu, You Wu, Zhi Li, Tian-Qi Xue   +5 more
doaj   +1 more source