Results 201 to 210 of about 1,289 (291)

Targeting KRAS for cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia   +4 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

open access: yesBritish Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo   +4 more
wiley   +1 more source

Non‐Rigid 3D Shape Correspondences: From Foundations to Open Challenges and Opportunities

open access: yesComputer Graphics Forum, EarlyView.
Abstract Estimating correspondences between deformed shape instances is a long‐standing problem in computer graphics; numerous applications, from texture transfer to statistical modelling, rely on recovering an accurate correspondence map. Many methods have thus been proposed to tackle this challenging problem from varying perspectives, depending on ...
A. Zhuravlev   +14 more
wiley   +1 more source

The Dimorphos ejecta plume properties revealed by LICIACube. [PDF]

open access: yesNature
Dotto E   +49 more
europepmc   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

open access: yesCell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang   +5 more
wiley   +1 more source

Disciplining Prostitutes in the Hospital de la Magdalena in Barcelona (1923‐1959)

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives The Hospital de la Magdalena, a care home for female prostitutes with venereal diseases, operated in Barcelona from 1923 to 1959. The purpose of this investigation is to highlight how this hospital was used to educate female prostitutes morally in addition to providing medical treatment.
Florian Grafl, Florian Steger
wiley   +1 more source

Dicyanoacetylene (NC<sub>4</sub>N) Formation in the CN + Cyanoacetylene (HC<sub>3</sub>N) Reaction: A Combined Crossed-Molecular Beams and Theoretical Study. [PDF]

open access: yesACS Earth Space Chem
Valença Ferreira de Aragão E   +8 more
europepmc   +1 more source

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