Results 131 to 140 of about 3,061,526 (262)

Poverty impact of state pension reform on the elderly: an analysis of reform proposals in the 2007 Irish green paper

, 2009
This report focuses on the relative poverty rate of Irish elderly, and aims to study the connection between potential changes to the state pension system and such poverty rates. The majority of Irish elderly depend in fact almost exclusively on the state
O’Donoghue, Cathal, Baroni, Elisa
core  

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Tackling Drugs at Local Level: A Policy Perspective

, 2001
Through the grants scheme entitled ‘Poverty, Drug Use and Policy - Developing Policy from Local Responses’, the Combat Poverty Agency supported seven local groups tackling drug-related issues in their areas through community development initiatives.
Combat Poverty Agency
core  

Combat Poverty Agency annual report 2004. [PDF]

, 2005
Combat Poverty Agency is a state advisory agency which develops and promotes evidence- based proposals and measures to combat poverty in Ireland. Our strategic priorities for the period 2005-2007 are to promote: • A fair distribution of income and ...

core  

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Poverty and the life cycle in 20th century Ireland: changing experiences of childhood, education and the transition to adulthood

, 2010
This study adds to the evidence base on poverty and the life cycle from a childhood centred perspective through a qualitative analysis of a major new database of life history interviews linked to a panel survey.
Gray, Jane
core  

Combat Poverty Agency annual report 2005. [PDF]

, 2006
Combat Poverty Agency is a state advisory agency which develops and promotes evidence- based proposals and measures to combat poverty in Ireland. Our strategic priorities for the period 2005-2007 are to promote: • A fair distribution of income and ...

core  

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Using rights-based approaches to tackle poverty: funded intitatives 2005

, 2006
Combat Poverty Agency believes that tackling poverty involv'es the recognition of economic, social and cultural rights, the eradication of discrimination and respect for diversity.
Combat Poverty Agency
core