Results 31 to 40 of about 3,061,526 (262)

Exploring OCD severity in treatment-seeking veterans: a cross-sectional comparison between post-traumatic stress disorder (PTSD) and complex-PTSD (C-PTSD)

BMC Psychology
The recent International Classifications of Diseases-11 (ICD-11) distinction of complex- post-traumatic stress disorder (C-PTSD) from post-traumatic stress disorder (PTSD), has highlighted a research gap in exploring how C-PTSD may relate to obsessive ...
Phoebe Howlett, Theadora Lilian Rose Sudera, Natasha Biscoe, Jo Billings, Dominic Murphy   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Association of potential morally injurious events, moral injury and somatic symptoms of health in UK military veterans: a cross-sectional study

BMC Psychology
Background Moral injury can follow exposure to three types of potentially morally injurious event (PMIE). Both PMIE exposure and moral injury are associated with poor health and functioning outcomes.
Gavin M. Campbell, Natasha Biscoe, Amanda Bonson, Dominic Murphy   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Situational copying strategies for the employees of the Federal service of the rosgvardi army

Сеченовский вестник, 2019
The article discusses the first results of studies of coping strategies of servicemen of the structure of Rosgvardia.The purpose of the study was to study the specifics and to analyze the coping strategies of the rank and file and the command structure of ...
T. R. Gizatullin, D. A. Mukhametova, D. R. Tansykkuzhina, V. N. Tsygan, L. A. Kuzhina, L. V. Lyamina, L. R. Akhmadeeva   +6 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Complex PTSD symptom clusters and executive function in UK Armed Forces veterans: a cross-sectional study

BMC Psychology
Background Less is known about complex posttraumatic stress disorder (CPTSD) than postrraumatic stress disorder (PTSD) in military veterans, yet this population may be at greater risk of the former diagnosis. Executive function impairment has been linked
Natasha Biscoe, Emma New, Dominic Murphy
doaj   +1 more source

Restore and Rebuild (R&R): a protocol for a phase 2, randomised control trial to compare R&R as a treatment for moral injury-related mental health difficulties in UK military veterans to treatment as usual

BMJ Open
Background Exposure to potentially morally injurious events is increasingly recognised as a concern across a range of occupational groups, including UK military veterans.
Dominic Murphy, Victoria Williamson, N Greenberg, Daniel Leightley, Natasha Biscoe, Amanda Bonson, Vicky Aldridge   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Defining military sexual trauma: establishing parameters and perspectives

European Journal of Psychotraumatology
Background: The term military sexual trauma [MST] is increasingly used to describe instances of sexual harassment/assault that occur between serving personnel during military service.
Charlotte Herriott, Gavin Campbell, Lauren Godier-McBard, Abigail Wood, Dominic Murphy   +4 more
doaj   +1 more source