Results 51 to 60 of about 17,986 (239)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The reintegration of former combatants in Colombia: addressing violent masculinities
, 2016 This article focuses on peace-building processes in fragile societies traumatised by violence and conflict. It argues that disarmament, demobilisation, and reintegration (DDR) programmes largely overlook the relationship between violent ‘militarised ...
Flisi, Isabella
core +1 more source
The Status of PMSC's Personnel Under International Humanitarian Law
Московский журнал международного права, 2015 Nowadays services of PMSCs are widely provided. Personnel of PMSC are involved in hostilities carrying out tasks related to the use of force. The article contains the analysis of the status of PMSC's personnel in accordance with international ...
Vyacheslav N. Kulebyakin +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
LawsArticle 43(2) of Additional Protocol I to the Geneva Conventions defines combatants but does not specify that they must be human. Bundle Theory, which views identity as a collection of rights and duties, suggests that legal personhood is unnecessary for ...
Johnny Sakr
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
DDRed in Liberia: Youth Remarginalisation or Reintegration? [PDF]
This report questions mainstream approaches to the reintegration of youthful ex-combatants. In Liberia, the disarmament and demobilisation was implemented quite effectively, but several questions can be asked about the components of reintegration and ...
Morten Bøås, Ingunn Bjørkhaug
core