Results 41 to 50 of about 11,656,079 (296)

Policy-maker attitudes to the ageing of the HIV cohort in Botswana

SAHARA-J, 2017
Background: The roll out of antiretroviral therapy in Botswana, as in many countries with near universal access to treatment, has transformed HIV into a complex yet manageable chronic condition and has led to the emergence of a population aging with HIV.
Kabo Matlho, Refelwetswe Lebelonyane, Tim Driscoll, Joel Negin   +3 more
doaj   +1 more source

DSP-0509, a systemically available TLR7 agonist, exhibits combination effect with immune checkpoint blockade by activating anti-tumor immune effects

Frontiers in Immunology, 2023
TLR7 is an innate immune receptor that recognizes single-stranded RNAs, and its activation leads to anti-tumor immune effects. Although it is the only approved TLR7 agonist in cancer therapy, imiquimod is allowed to be administered with topical ...
Yosuke Ota, Yasuhiro Nagai, Yuko Hirose, Seiji Hori, Erina Koga-Yamakawa, Ken Eguchi, Kentaro Sumida, Masashi Murata, Hiroki Umehara, Setsuko Yamamoto   +9 more
doaj   +1 more source

Combination Strategies for Semantic Role Labeling

, 2011
This paper introduces and analyzes a battery of inference models for the problem of semantic role labeling: one based on constraint satisfaction, and several strategies that model the inference as a meta-learning problem using discriminative classifiers.
Carreras, X., Comas, P. R., Marquez, L., Surdeanu, M.   +3 more
core   +1 more source

Combination of molecular similarity measures using data fusion [PDF]

, 2000
Many different measures of structural similarity have been suggested for matching chemical structures, each such measure focusing upon some particular type of molecular characteristic.
Bradshaw, J., Ginn, C.M.R., Willett, P.
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Temperature-density dependent hidden order of amorphous carbon

Communications Physics
The microscopic structure of amorphous carbon is inherently complex, and its underlying topological order remains poorly understood. Here, we developed a high-precision machine learning potential and performed large-scale molecular dynamics simulations ...
Yutao Liu, Tinghong Gao, Qingquan Xiao, Yunjun Ruan, Qian Chen, Bei Wang, Jin Huang   +6 more
doaj   +1 more source

Optimization of Effluent Phosphorus Control for Al-Aziziah (Wasit) Wastewater Treatment Plant

Wasit Journal of Engineering Sciences, 2015
The combination between the enhance biological phosphorus removal EBPR process and chemical phosphorous precipitation process removal from wastewater to avoid the instability of the biological phosphorus removal process due to temperature variation has ...
Mohammed Siwan Shamkhi
doaj   +1 more source

An augmented three-pass system combination framework: DCU combination system for WMT 2010 [PDF]

, 2010
This paper describes the augmented threepass system combination framework of the Dublin City University (DCU) MT group for the WMT 2010 system combination task. The basic three-pass framework includes building individual confusion networks (CNs), a
Du, Jinhua, Pecina, Pavel, Way, Andy
core  

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Combination Therapy [PDF]

Journal of Managed Care Pharmacy, 2003
Adult Treatment Panel III (ATP III) guidelines recommend specific treatment targets for low-density lipoprotein cholesterol (LDL-C) levels according to an individual.s short-term and long-term risk for coronary heart disease (CHD). Therapeutic lifestyle changes are recommended for all patients at any level of risk for CHD.
openaire   +2 more sources