The use of mono- and combination drug therapy in men and women with lower urinary tract symptoms (LUTS) in the UK: a retrospective observational study [PDF]
BMC Urology, 2021 Background Combination drug therapy for lower urinary tract symptoms (LUTS) is beneficial to selected patients and recommended by guidelines. Patterns of real-world LUTS drug use, especially combination drug therapy, have not been studied extensively ...
Mahmood Ali +6 more
doaj +4 more sources
Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease [PDF]
Brain Sci, 2021 Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs).
Hafsa Amat-ur-Rasool +3 more
europepmc +3 more sources
Emergence of prions selectively resistant to combination drug therapy. [PDF]
PLoS Pathogens, 2020 Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc.
Cassandra M Burke +4 more
doaj +3 more sources
Analysis of Combination Drug Therapy to Develop Regimens with Shortened Duration of Treatment for Tuberculosis [PDF]
PLoS One, 2014 Rationale Tuberculosis remains a worldwide problem, particularly with the advent of multi-drug resistance. Shortening therapy duration for Mycobacterium tuberculosis is a major goal, requiring generation of optimal kill rate and resistance-suppression ...
George L. Drusano +7 more
europepmc +4 more sources
Combination Drug Therapy for the Management of Chronic Neuropathic Pain. [PDF]
Biomolecules, 2023 Chronic neuropathic pain (NP) is an increasingly prevalent disease and leading cause of disability which is challenging to treat. Several distinct classes of drugs are currently used for the treatment of chronic NP, but each drug targets only narrow ...
Boccella S +14 more
europepmc +2 more sources
Sickle cell disease: progress towards combination drug therapy. [PDF]
Br J Haematol, 2021 Dr. John Herrick described the first clinical case of sickle cell anaemia (SCA) in the United States in 1910. Subsequently, four decades later, Ingram and colleagues characterized the A to T substitution in DNA producing the GAG to GTG codon and ...
Pace BS, Starlard-Davenport A, Kutlar A.
europepmc +2 more sources
Combination Drug Therapy for the Management of Alzheimer's Disease. [PDF]
Int J Mol Sci, 2020 Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Even though the number of AD patients is rapidly growing, there is no effective treatment for this neurodegenerative disorder.
Kabir MT +9 more
europepmc +2 more sources
Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis. [PDF]
Pharmacol Res Perspect, 2020 Today, monotherapy is the most common pharmacological treatment option for patients suffering from overactive bladder (OAB). Recent reports have indicated potential benefits of combination therapy, using a muscarinic antagonist and a β3‐adrenoceptor ...
Patel B +5 more
europepmc +2 more sources
Influenza Treatment: Limitations of Antiviral Therapy and Advantages of Drug Combination Therapy
Microorganisms, 2023 Influenza infection is serious and debilitating for humans and animals. The influenza virus undergoes incessant mutation, segment recombination, and genome reassortment.
Sania Batool +2 more
doaj +2 more sources
HSA-based multi-target combination therapy: regulating drugs’ release from HSA and overcoming single drug resistance in a breast cancer model [PDF]
Drug Delivery, 2018 Multi-drug delivery systems, which may be promising solution to overcome obstacles, have limited the clinical success of multi-drug combination therapies to treat cancer.
Yi Gou +12 more
doaj +2 more sources