Results 131 to 140 of about 2,657,261 (342)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC SYNDROME. THE ROLE OF THE COMBINATION DRUGS

Рациональная фармакотерапия в кардиологии, 2015
Data about the current approach to the choice of dual antihypertensive combinations in various clinical situations for treatment of hypertension are presented.
A. M. Shilov, M. S. Dulaeva, A. O. Osia, A. S. Lishuta   +3 more
doaj   +1 more source

Combination Drug Therapy for Persistent Pulmonary Hypertension of the Newborn [PDF]

, 2017
Noritaka Yokoo, Chieko Marumo, Yoshinobu Nishida, Jun Iio, Shinji Maeda, Michiko Nonaka, Toshiro Maihara   +6 more
openalex   +1 more source

A case of progressive multifocal leukoencephalopathy in a post-kidney transplant patient with improvement after discontinuation of immunosuppressive drugs and combination therapy with mefloquine and mirtazapine [PDF]

, 2023
Neri Sone, Hiroki Nishiwaki, Mayu Shimokawa, Keishu Kawanishi, Tsuyoshi Oshiro, Reiji Takami, Natsuki Taira, Masahito Amagasa, Shinya Omiya, Tadahide Maezumi, Yoko Nabeshima, Kazuo Nakamichi, Yoshiharu Miura, Fumihiko Koiwa   +13 more
openalex   +1 more source

Comparing Triple Combination Drug Therapy and Traditional Monotherapy for Better Survival in Patients With High-Risk Hypertension: A Systematic Review. [PDF]

Cureus, 2023
Zaman MA, Awais N, Satnarine T, Ahmed A, Haq A, Patel D, Gutlapalli SD, Hernandez GN, Seffah K, Khan S.   +9 more
europepmc   +1 more source

Drug‑Drug and Drug‑Nutraceutical Cocrystal/Salt as Alternative Medicine for Combination Therapy: A Crystal Engineering Approach

, 2018
The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal engineering that has emerged as a promising technique for drug development in pharmaceutical industry.
Ranjit Thakuria, B. Sarma
semanticscholar   +1 more source

Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies

PLoS Comput. Biol., 2017
Multiple treatment strategies are available for empiric antibiotic therapy in hospitals, but neither clinical studies nor theoretical investigations have yielded a clear picture when which strategy is optimal and why. Extending earlier work of others and
Burcu Tepekule, Hildegard Uecker, I. Derungs, Antoine Frénoy, S. Bonhoeffer   +4 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Medical use and combination drug therapy among US adult users of central nervous system stimulants: a cross-sectional analysis. [PDF]

BMJ Open, 2023
Moore TJ, Wirtz PW, Curran JN, Alexander GC.   +3 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source