The Efficacy of Using Combination Therapy against Multi-Drug and Extensively Drug-Resistant Pseudomonas aeruginosa in Clinical Settings [PDF]
, 2022 Frank R. Jones +2 more
openalex +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Sickle cell disease: progress towards combination drug therapy. [PDF]
Br J Haematol, 2021 Pace BS, Starlard-Davenport A, Kutlar A.
europepmc +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015 Purpose: Selection and use of anti-hypertensive agents are not usually compliant with international guidelines. A prescription based survey is the most effective method to assess and evaluate the prescribing pattern of physicians and dispensing practice ...
Fanta Gashe Fufa +2 more
doaj
Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma
Frontiers in PharmacologyBackgroundAbnormalities in trace elements and the incidence of oesophageal squamous cell carcinoma (ESCC) have been reported in China. Zinc ions (Zn2+) are known to regulate DNA methylation by stabilizing methylase activity.
Bin Zhou +11 more
doaj +1 more source
Efficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial [PDF]
, 2018 Nam Hoon Kim +8 more
openalex +1 more source
Evaluation of a 12-week allopurinol-lowering therapy in combination with the non-steroidal anti-inflammatory drug meloxicam in patients with gout [PDF]
, 2020 Margarita Aleksandrovna Gromova +3 more
openalex +1 more source