The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil
Cadernos de Saúde Pública, 2000 We investigated the impact of multidrug therapy (MDT) on the epidemiological pattern of leprosy in Juiz de Fora, Brazil, from 1978 to 1995. Evaluation of 1,283 medical charts was performed according to the treatment regimen used in two different periods.
Soares Luzivander S. +6 more
doaj
Combination Drug Therapy for the Management of Alzheimer’s Disease
Российский журнал гериатрической медициныAlzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. It is the leading cause of dementia in both older and oldest old population.
N. G. Dudchenko, E. A. Mkhitaryan
doaj +1 more source
Comparison of Single vs Combination Drug Therapy in Extensively Drug Resistant Salmonella typhi: An Observational Study from Pakistan. [PDF]
Infect Drug Resist, 2022 Ishaque S, Syed B, Dodani SK, Anwar S.
europepmc +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
The Efficacy of Using Combination Therapy against Multi-Drug and Extensively Drug-Resistant Pseudomonas aeruginosa in Clinical Settings [PDF]
, 2022 Frank R. Jones +2 more
openalex +1 more source
Expanding role for single-pill combination drug therapy in the initial treatment of hypertension? [PDF]
J Clin Hypertens (Greenwich), 2021 Li Y +7 more
europepmc +1 more source
Incidence of HIV-1 Drug Resistance Among Antiretroviral Treatment-Naive Individuals Starting Modern Therapy Combinations [PDF]
, 2017 By use of simulations we imputed human immunodeficiency virus type 1 drug resistance incidence to protease inhibitor-based or nonnucleoside reverse-transcriptase inhibitor-based combination therapy.
Battegay, Manuel +13 more
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source