Results 151 to 160 of about 2,657,261 (342)

Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial

Frontiers in Neurology
ObjectiveThis study tested the hypothesis that a neuroprotective combined therapy based on epidermal growth factor (EGF) and growth hormone-releasing hexapeptide (GHRP6) could be safe for acute ischemic stroke patients, admitting up to 30% of serious ...
Francisco Hernández-Bernal, Francisco Hernández-Bernal, Donner Estenoz-García, Juan H. Gutiérrez-Ronquillo, Yenima Martín-Bauta, Karen Catasús-Álvarez, Mario Gutiérrez-Castillo, Marbelys Guevara-Rodríguez, Aliuska Castro-Jeréz, Yoandra Fuentes-González, Yulemis Pinto-Cruz, Carmen Valenzuela-Silva, Verena L. Muzio-González, Héctor Pérez-Saad, Nelvys Subirós-Martínez, Gerardo E. Guillén-Nieto, Gerardo E. Guillén-Nieto, Diana Garcia-del-Barco-Herrera, Diana Garcia-del-Barco-Herrera   +18 more
doaj   +1 more source

P456 Drug survival of thiopurine–allopurinol combination therapy in a real-life population-based cohort [PDF]

, 2018
Joany E. Kreijne, Rozanne C. de Veer, Nanne K.H. de Boer, Xiong Ma, Gerard Dijkstra, Rachel West, Ad A. van Bodegraven, Dirk J. de Jong, C. Janneke van der Woude, Annemarie C. de Vries   +9 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Drug combination therapy for emerging viral diseases

Drug Discovery Today, 2021
Zeenat A. Shyr, Yu‐Shan Cheng, D. Lo, Wei Zheng   +3 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Prevalence of Drug-Resistant HIV-1 Variants in Untreated Individuals in Europe: Implications for Clinical Management [PDF]

, 2017
BackgroundInfection with drug-resistant human immunodeficiency virus type 1 (HIV-1) can impair the response to combination therapy. Widespread transmission of drug-resistant variants has the disturbing potential of limiting future therapy options and ...
Angarano, Gioacchino, Balotta, Claudia, Boeri, Enzo, Boucher, Charles A., Camacho, Ricardo, Chaix, Maire-Laure, Costagliola, Dominique, De Luca, Andrea, de Mendoza, Carmen, Derdelinckx, Inge, Grossman, Zehava, Hamouda, Osamah, Hatzakis, Angelos, Hemmer, Robert, Hoepelman, Andy, Horban, Andrzej, Korn, Klaus, Kücherer, Claudia, Leitner, Thomas, Loveday, Clive, MacRae, Eilidh, Maljkovic, Irina, Meyer, Laurence, Nielsen, Claus, Op de Coul, Eline L., Ormaasen, Vidar, Paraskevis, Dimitris, Perrin, Luc, Puchhammer-Stöckl, Elisabeth, Ruiz, Lidia, Salminen, Mika, Schmit, Jean-Claude, Schneider, Francois, Schuurman, Rob, Soriano, Vincent, Stanczak, Grzegorz, Stanojevic, Maja, van de Vijver, David A., Van Laethem, Kristel, Vandamme, Anne-Mieke, Violin, Michela, Wensing, Annemarie M. J., Wilbe, Karin, Yerly, Sabine, Zazzi, Maurizio, Åsjö, Birgitta   +45 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma

Frontiers in Pharmacology
BackgroundAbnormalities in trace elements and the incidence of oesophageal squamous cell carcinoma (ESCC) have been reported in China. Zinc ions (Zn2+) are known to regulate DNA methylation by stabilizing methylase activity.
Bin Zhou, Bin Zhou, Changchun Wang, Yueyu Huang, Xuping Yang, Ting Ye, Lize Shen, Qiaoli Lv, Weimin Mao, Weimin Mao, An Zhao, An Zhao   +11 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Potential Combination Drug Therapy to Prevent Redox Stress and Mitophagy Dysregulation in Retinal Müller Cells under High Glucose Conditions: Implications for Diabetic Retinopathy. [PDF]

Diseases, 2021
Singh LP, Devi TS.
europepmc   +1 more source