Results 151 to 160 of about 1,434,198 (304)

Photodynamic therapy and adapalene in dermatology: synergistic effects in immortal human keratinocytes [PDF]

, 2013
We compared the effects of methyl levulinate (MAL)/photodynamic therapy (PDT) and adapalene, evaluated singly, versus combination therapy on HaCaT keratinocytes.
ANNUNZIATA, MARIA CARMELA, CHIAVIELLO, ANGELA, FABBROCINI, GABRIELLA, MONFRECOLA, GIUSEPPE, PALUMBO, GIUSEPPE, POSTIGLIONE, ILARIA   +5 more
core  

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Prevalence of Drug-Resistant HIV-1 Variants in Untreated Individuals in Europe: Implications for Clinical Management [PDF]

, 2017
BackgroundInfection with drug-resistant human immunodeficiency virus type 1 (HIV-1) can impair the response to combination therapy. Widespread transmission of drug-resistant variants has the disturbing potential of limiting future therapy options and ...
Angarano, Gioacchino, Balotta, Claudia, Boeri, Enzo, Boucher, Charles A., Camacho, Ricardo, Chaix, Maire-Laure, Costagliola, Dominique, De Luca, Andrea, de Mendoza, Carmen, Derdelinckx, Inge, Grossman, Zehava, Hamouda, Osamah, Hatzakis, Angelos, Hemmer, Robert, Hoepelman, Andy, Horban, Andrzej, Korn, Klaus, Kücherer, Claudia, Leitner, Thomas, Loveday, Clive, MacRae, Eilidh, Maljkovic, Irina, Meyer, Laurence, Nielsen, Claus, Op de Coul, Eline L., Ormaasen, Vidar, Paraskevis, Dimitris, Perrin, Luc, Puchhammer-Stöckl, Elisabeth, Ruiz, Lidia, Salminen, Mika, Schmit, Jean-Claude, Schneider, Francois, Schuurman, Rob, Soriano, Vincent, Stanczak, Grzegorz, Stanojevic, Maja, van de Vijver, David A., Van Laethem, Kristel, Vandamme, Anne-Mieke, Violin, Michela, Wensing, Annemarie M. J., Wilbe, Karin, Yerly, Sabine, Zazzi, Maurizio, Åsjö, Birgitta   +45 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimizing drug combination and mechanism analysis based on risk pathway crosstalk in pan cancer

Scientific Data
Combination therapy can greatly improve the efficacy of cancer treatment, so identifying the most effective drug combination and interaction can accelerate the development of combination therapy.
Congxue Hu, Wanqi Mi, Feng Li, Lun Zhu, Qi Ou, Maohao Li, Tengyue Li, Yuheng Ma, Yunpeng Zhang, Yingqi Xu   +9 more
doaj   +1 more source

Combination Drug Therapy for the Management of Alzheimer's Disease. [PDF]

Int J Mol Sci, 2020
Kabir MT, Uddin MS, Mamun AA, Jeandet P, Aleya L, Mansouri RA, Ashraf GM, Mathew B, Bin-Jumah MN, Abdel-Daim MM.   +9 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Supramonomer‐Based Glyco‐Cationic Nanoparticles With GSH Depletion‐Enhanced Drug/Gene Co‐Delivery for Combination Therapy [PDF]

Yuchao Lu, Tian Shi, Wanqiang Liu, Danhong Shang, Xinping Liu, Qiang Wang, Xue Yang, Xinyue Ge, Yanjie Jia, Pengkun He, Kai Zhang, Changping Hu, Lan Chen, Xiao Duan   +13 more
openalex   +1 more source