Results 161 to 170 of about 2,657,261 (342)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Prescription Pattern and Potential Drug-Drug Interactions of Antihypertensive Drugs in a General Hospital, South Ethiopia

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015
Purpose: Selection and use of anti-hypertensive agents are not usually compliant with international guidelines. A prescription based survey is the most effective method to assess and evaluate the prescribing pattern of physicians and dispensing practice ...
Fanta Gashe Fufa, Dereje Mirkano, Ramenjiredi Tipathi   +2 more
doaj  

The lag time in initiating clinical testing of new drugs in combination with radiation therapy, a significant barrier to progress? [PDF]

, 2014
Philip Blumenfeld, Raphael M. Pfeffer, Zvi Symon, Robert B. Den, Adam P. Dicker, David Raben, Yaacov Richard Lawrence   +6 more
openalex   +1 more source

Identification and validation of a prognostic signature and combination drug therapy for immunotherapy of head and neck squamous cell carcinoma. [PDF]

Comput Struct Biotechnol J, 2021
Qiang W, Dai Y, Xing X, Sun X.
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Azole Combinations and Multi-Targeting Drugs That Synergistically Inhibit Candidozyma auris

Journal of Fungi
Limited antifungal treatment options and drug resistance require innovative approaches to effectively combat fungal infections. Combination therapy is a promising strategy that addresses these pressing issues by concurrently targeting multiple cellular ...
Stephanie Toepfer, Mikhail V. Keniya, Michaela Lackner, Brian C. Monk   +3 more
doaj   +1 more source

Myeloid-Related Proteins 8/14 Failed to Act as Theragnostic Biomarker in Axial Spondyloarthritis Patients on Combination Disease-Modifying Anti-Rheumatic Drugs Therapy

, 2020
Debashish Danda, Arvind Ganapati, Jayakanthan Kabeerdoss, Mahasampath Gowri, Belavendra Antonisamy   +4 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The impact of multidrug therapy on the epidemiological pattern of leprosy in Juiz de Fora, Brazil

Cadernos de Saúde Pública
We investigated the impact of multidrug therapy (MDT) on the epidemiological pattern of leprosy in Juiz de Fora, Brazil, from 1978 to 1995. Evaluation of 1,283 medical charts was performed according to the treatment regimen used in two different periods.
Luzivander S. Soares, Rodrigo de O. Moreira, Vanessa V. Vilela, Márcio J. M. Alves, Ana Flávia M. Pimentel, Ana Paula Ferreira, Henrique C. Teixeira   +6 more
doaj  

Photodynamic therapy and adapalene in dermatology: synergistic effects in immortal human keratinocytes [PDF]

, 2013
We compared the effects of methyl levulinate (MAL)/photodynamic therapy (PDT) and adapalene, evaluated singly, versus combination therapy on HaCaT keratinocytes.
ANNUNZIATA, MARIA CARMELA, CHIAVIELLO, ANGELA, FABBROCINI, GABRIELLA, MONFRECOLA, GIUSEPPE, PALUMBO, GIUSEPPE, POSTIGLIONE, ILARIA   +5 more
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