Results 221 to 230 of about 2,657,261 (342)

Evaluation of Combination Drug Therapy for Treatment of Antibiotic-Resistant Inhalation Anthrax in a Murine Model. [PDF]

Antimicrob Agents Chemother, 2017
Heine HS, Shadomy SV, Boyer AE, Chuvala L, Riggins R, Kesterson A, Myrick J, Craig J, Candela MG, Barr JR, Hendricks K, Bower WA, Walke H, Drusano GL.   +13 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy

, 2021
Yaw Opoku‐Damoah, Run Zhang, Hang T. Ta, Zhi Ping Xu   +3 more
openalex   +2 more sources

Granulomatous cheilitis: successful treatment of two recalcitrant cases with combination drug therapy. [PDF]

Case Rep Dermatol Med, 2014
Gupta A, Singh H.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A novel combination therapy for ER+ breast cancer suppresses drug resistance via an evolutionary double-bind

Rena Emond, Jeffrey West, Vince Kornél Grolmusz, Patrick A. Cosgrove, Aritro Nath, Alexander R.A. Anderson, Andrea H. Bild   +6 more
openalex   +1 more source

A COMPARATIVE STUDY ON EFFICACY OF FIXED COMBINATION TIMOLOL/BRINZOLAMIDE VERSUS TRAVOPROST MONO-THERAPY IN DRUG-NAÏVE OPEN-ANGLE GLAUCOMA PATIENTS.

, 2020
Munib Ur Rehman, Shahid Mehmood Diyal, Bilal Humayun Mirza, Iqra Qureshi, Muhammad Rizwan Ullah   +4 more
openalex   +2 more sources

Economic impact of combination therapy with infliximab plus azathioprine for drug-refractory Crohn's disease: A cost-effectiveness analysis [PDF]

, 2012
Shota Saito, Utako Shimizu, Nan Zhang, Nozomu Mandai, Junji Yokoyama, Kenshi Terajima, Kouhei Akazawa   +6 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy [PDF]

, 2009
Alexander NO Dodoo, Carole Fogg, Alex Asiimwe, Edmund T. Nartey, Augustina Kodua, Ofori Tenkorang, David Ofori‐Adjei   +6 more
openalex   +1 more source