Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis
Frontiers in Cellular and Infection Microbiology, 2023 Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Talia Greenstein +5 more
doaj +1 more source
High Drug-Loading Nanomedicines for Tumor Chemo–Photo Combination Therapy: Advances and Perspectives
Pharmaceutics, 2022 The combination of phototherapy and chemotherapy (chemo–photo combination therapy) is an excellent attempt for tumor treatment. The key requirement of this technology is the high drug-loading nanomedicines, which can load either chemotherapy drugs or ...
Ya Wang +6 more
doaj +1 more source
Understanding and targeting resistance mechanisms in cancer
MedComm, 2023 Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei +6 more
doaj +1 more source
Recent Advances in Curcumin-Based Combination Nanomedicines for Cancer Therapy
Journal of Functional Biomaterials, 2023 Standard cancer chemotherapeutics often produce significant adverse effects and eventually lose their effectiveness due to the emergence of resistance mechanisms.
Amir R. Afshari +3 more
doaj +1 more source
Structured Decentralized Control of Positive Systems With Applications to Combination Drug Therapy and Leader Selection in Directed Networks [PDF]
IEEE Transactions on Control of Network Systems, 2017 We study a class of structured optimal control problems in which the main diagonal of the dynamic matrix is a linear function of the design variable. While such problems are in general challenging and nonconvex, for positive systems we prove convexity of
Neil K. Dhingra +2 more
semanticscholar +1 more source
Independent Drug Action in Combination Therapy: Implications for Precision Oncology
Cancer Discovery, 2022 Combination therapies are superior to monotherapy for many cancers. This advantage was historically ascribed to the ability of combinations to address tumor heterogeneity, but synergistic interaction is now a common explanation as well as a design ...
D. Plana, A. Palmer, P. Sorger
semanticscholar +1 more source
Advancement of science, 2021 Nanomedicines with photodynamic therapy and reactive oxygen species (ROS)‐triggered drug release capabilities are promising for cancer therapy. However, most of the nanomedicines based on ROS‐responsive nanocarriers still suffer from serious ROS ...
Sheng Wang +8 more
semanticscholar +1 more source
pH-Sensitive Peptide Hydrogels as a Combination Drug Delivery System for Cancer Treatment
Pharmaceutics, 2022 Conventional antitumor chemotherapeutics generally have shortcomings in terms of dissolubility, selectivity and drug action time, and it has been difficult to achieve high antitumor efficacy with single-drug therapy.
Yuan-fen Liu +11 more
semanticscholar +1 more source
Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L. +8 more
core +6 more sources
Open Journal of Psychiatry and Allied Sciences, 2016 Objective: To study the prescribing pattern of antipsychotic drugs in the outpatient department of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam.
Pinaki Chakravarty +2 more
doaj +1 more source