Results 61 to 70 of about 1,434,198 (304)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model. [PDF]

, 2013
The current first-line treatment for advanced metastatic prostate cancer, i.e. docetaxel-based therapy, is only marginally effective. The aim of the present study was to determine whether such therapy can be improved by combining docetaxel with Aneustat (
Collins, Colin C, Gao, Allen C, Gout, Peter W, Liu, Chengfei, Qu, Sifeng, Wang, Kendric, Wang, Yuwei, Wang, Yuzhuo, Wu, Rebecca, Xue, Hui   +9 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Trigeminal neuralgia: successful antiepileptic drug combination therapy in three refractory cases

Drug, Healthcare and Patient Safety, 2011
Lara Prisco1, Mario Ganau2, Federica Bigotto1, Francesca Zornada11Department of Anaesthesiology, Intensive Care and Emergency Medicine, University Hospital of Cattinara, 2Graduate School of Nanotechnology, University of Trieste, ItalyAbstract ...
Prisco L, Ganau M, Bigotto F, Zornada F
doaj  

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Resistance to antibody–drug conjugates: A review

Acta Pharmaceutica Sinica B
Antibody–drug conjugates (ADCs) are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker. Currently, 15 ADCs have been clinically approved worldwide.
Sijia Li, Xinyu Zhao, Kai Fu, Shuangli Zhu, Can Pan, Chuan Yang, Fang Wang, Kenneth K.W. To, Liwu Fu   +8 more
doaj   +1 more source

Vitamin C, doxycycline, and azithromycin (VDA) targeted changes in cellular senescence-related genes in human adipose-derived mesenchymal stem cells [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Adipose-derived Mesenchymal stem cells (ASCs) have garnered attention for their regenerative potential; therefore, their cellular senescence-related gene expression remains crucial in therapeutic contexts.
Roshanak Alvandi, Samira Salimiyan, Mohammad Moradzad, Mobin Mohammadi, Shohreh Fakhari, Mohammad Rahmani   +5 more
doaj   +1 more source

The Microglial Activation Inhibitor Minocycline, Used Alone and in Combination with Duloxetine, Attenuates Pain Caused by Oxaliplatin in Mice

Molecules, 2021
The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition.
Kinga Sałat, Anna Furgała-Wojas, Robert Sałat   +2 more
doaj   +1 more source

Systems approaches and algorithms for discovery of combinatorial therapies

, 2009
Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks.
Agoston V, Balamurugan D, Calzolari D, Carlson JM, Greco WR, Johannesson GH, Nelander S, Segota E, Spall JC, Wadman M, Weinberg RA, Yang K   +11 more
core   +1 more source

Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim [PDF]

, 2014
Background: A common approach to cancer therapy in clinical practice is the combination of several drugs to boost the anticancer activity of available drugs while suppressing their unwanted side effects.
A Hubner, AC Bellail, B Al-Lazikani, BH Kang, BH Kang, BH Kang, BH Kang, BH Kang, BL Bennett, Byoung Heon Kang, C Liedtke, Da-Eun Jo, DD Von Hoff, EA Lefrak, F Maddalena, G Kroemer, G Minotti, GV Putcha, H Puthalakath, H Yamaguchi, Hye-Kyung Park, I Leav, J Hagenbuchner, J Trepel, Jaehwa Lim, JC Wang, Ji-Eun Lee, K Lei, K Subik, M Sciacovelli, M Taipale, MC Caino, MD Siegelin, N Lopez-Royuela, Pann-Ghill Suh, PK Singal, R Ley, RJ Youle, RM Sramkoski, S Yoshida, SJ Felts, SJ Kim, Soo-Ah Park, T Hattori, T Panaretakis, TC Chou, YC Chae, YC Chae, YJ Kang   +48 more
core   +1 more source