Results 121 to 130 of about 9,546,669 (393)

Highlights in Resistance Mechanism Pathways for Combination Therapy

Cells, 2019
Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most ...
João M A Delou, A. S. Souza, L. C. M. Souza, H. Borges   +3 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Nature, 2022
M. Hashimoto, K. Araki, M. Cardenas, Peng Li, R. Jadhav, H. Kissick, W. Hudson, D. McGuire, Rebecca C. Obeng, A. Wieland, Judong Lee, Daniel T. McManus, J. Ross, S. Im, JungHwa Lee, Jian-Xin Lin, B. Hu, E. West, Christopher D. Scharer, G. Freeman, A. Sharpe, S. Ramalingam, A. Pellerin, V. Teichgräber, W. Greenleaf, C. Klein, J. Goronzy, P. Umaña, W. Leonard, Kendall A. Smith, R. Ahmed   +30 more
semanticscholar   +1 more source

Combination Therapy Strategies for the Treatment of Malaria

Molecules, 2019
Malaria is a vector- and blood-borne infection that is responsible for a large number of deaths around the world. Most of the currently used antimalarial therapeutics suffer from drug resistance.
S. Alven, B. Aderibigbe
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Adherence to self-administered tuberculosis treatment in a high HIV-prevalence setting: a cross-sectional survey in Homa Bay, Kenya. [PDF]

, 2012
Good adherence to treatment is crucial to control tuberculosis (TB). Efficiency and feasibility of directly observed therapy (DOT) under routine program conditions have been questioned.
AK Person, Apollo Odongo Aloo, B Blomberg, C Lienhardt, Claire Thorne, DK Mafigiri, DR Bangsberg, DR Bangsberg, Emmanuelle Espié, FA Kaona, Fabienne Nackers, Francis Varaine, G Fochsen, G Verma, H Huerga, Helena Huerga, J Connor, J Elizaga, J Macq, J Sim, J Volmink, Jean-François Etard, Jeremiah Chakaya, JH Oyugi, Joseph Sitienei, KR Amico, L Osterberg, L Tuyisenge, Maryline Bonnet, Mathieu Bastard, ME Raguenaud, MJ Selgelid, MS Pepe, N Awofeso, PE Meissner, R Steffen, RA Atun, S Bangalore, S Mannheimer, SA Munro, SB Mannheimer, SC Kalichman, SM Youngleson, TA Szakacs, TP Giordano, W Xu, WA Kaplan   +46 more
core   +5 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Combination therapy for hypertension [PDF]

, 2003
published_or_final_versio
Cheung, BMY, Kumana, CR, Lau, CP
core  

The value of using sandplay as a tool for counselling within a school setting [PDF]

, 2004
This paper proposes that sandplay can be a useful tool for counsellors within the school setting. It follows previous work by O'Brien and Burnett (2000a, 2000b; O'Brien,1999), who proposed that sandplay allows the counsellor to integrate all eight ...
O'Brien, Patrick, Tunnecliff, Sheryl
core   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source