Results 151 to 160 of about 9,546,669 (393)

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup. [PDF]

, 2017
Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer–associated ...
Alshalalfa, Mohammed, Bowden, Michaela, Brown, Myles, Davicioni, Elai, Den, Robert B., Ellis, Leigh, Eng, Kevin H., Erho, Nicholas, Feng, Felix Y., Galbo, Phillip, Goodrich, David W., Gray, Kathryn P., Huang, Ying, Jenkins, Robert B., Karnes, R. Jeffrey, Ku, Sheng-Yu, Labbé, David P., Rosario, Spencer, Ross, Ashley E., Schaeffer, Edward M., Sjöström, Martin, Spratt, Daniel E., Sweeney, Christopher J., Wadosky, Kristine M.   +23 more
core   +2 more sources

Studies of Sequential and Combination Antimetabolite Therapy in Acute Leukemia: 6-Mercaptopurine and Methotrexate [PDF]

, 1961
Emil Frei, Emil J. Freireich, Edmund A. Gehan, Donald Pinkel, James F. Holland, Oleg S. Selawry, Farid I. Haurani, Charles L. Spurr, Donald M. Hayes, G. Watson James, Harvey Rothberg, D. Bruce Sodee, R. Wayne Rundles, LESLIE R. SCHROEDER, Barth Hoogstraten, Irving J. Wolman, Demetrius Traggis, Talbert Cooper, Benjamin R. Gendel, Franklin G. Ebaugh, Robert Taylor   +20 more
openalex   +1 more source

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

International Journal of Molecular Sciences, 2018
Cancer represents a group of heterogeneous diseases characterized by uncontrolled growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a significant role in the development of nanodrugs, nanodevices, drug delivery systems ...
Sangiliyandi Gurunathan, M. Kang, Muhammad Qasim, Jin-Hoi Kim   +3 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Full-dose combinations of antihypertensive drugs: What has changed in experts' guidelines?

Терапевтический архив, 2014
The 2013 European Society of Hypertension guidelines, including treatment policy changes presupposing that one two-component combination of antihypertensive agents may be substituted for another and their full-dose combinations may be prescribed if ...
V V Fomin, A A Svistunov
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Sodium–glucose cotransporter-2 inhibitor combination therapy to optimize glycemic control and tolerability in patients with type 2 diabetes: focus on dapagliflozin–metformin

Diabetes, Metabolic Syndrome and Obesity, 2016
Stanley S Schwartz,1,2 Arie Katz3 1University of Pennsylvania, Philadelphia, PA, USA; 2Main Line Health System, Ardmore, PA, USA; 3AstraZeneca, Fort Washington, PA, USA Abstract: In type 2 diabetes (T2D), early combination therapy using agents that ...
Schwartz SS, Katz A
doaj  

Modulator Therapy for Cystic Fibrosis: An Exploration of Current Research [PDF]

, 2020
Developing a drug therapy that addresses the root cause of cystic fibrosis (CF) by increasing CFTR protein levels has long been a research challenge. After genetic therapy failed because a suitable delivery system could not be found, researchers began ...
Rombocos, Jessalyn
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Simultaneous treatment with benralizumab and ustekinumab in a patient with severe asthma and ulcerative colitis

Lung India
The burden of autoimmune diseases is rising worldwide. The expansion of the population of patients eligible for severe asthma biological therapy we are seeing in clinical practice could lead to the simultaneous use of different monoclonal antibodies.
Lorenzo Carriera, Roberto Barone, Simone Ielo, Angelo Coppola   +3 more
doaj   +1 more source