Results 41 to 50 of about 166,183,559 (213)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Optimal blocked minimum-support designs for non-linear models
, 2014 Finding optimal designs for experiments for non-linear models and dependent data is a challenging task. We show how the problem simplifies when the search is restricted to designs that are minimally supported; that is, the number of distinct runs ...
van de Ven, P.M., Woods, D.C.
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Combinatorial Designs with Two Singular Values I. Uniform Multiplicative Designs [PDF]
In this and a sequel paper [10] we study combinatorial designs whose incidence matrix has two distinct singular values.These generalize 2-(v, k, É) designs, and include partial geometric designs and uniform multiplicative designs.Here we study the latter,
Spence, E., Dam, E.R. van
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Combinatorial designs: a tribute to Haim Hanani [PDF]
, 1989 Haim Hanani pioneered the techniques for constructing designs and the theory of pairwise balanced designs, leading directly to Wilson''s Existence Theorem.
Hartman, A, Hartman, Alan
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Optimal designs for an interference model [PDF]
Kunert and Martin (2000) determined optimal and efficient block designs in a model for field trials with interference effects, for block sizes up to 4. In this paper we use Kushner's method (Kushner, 1997) of finding optimal approximate designs to extend
Kunert, Joachim, Mersmann, Sabine
core
On eigenfunctions of the block graphs of geometric Steiner systems [PDF]
This paper lies in the context of the studies of eigenfunctions of graphs having minimum cardinality of support. One of the tools is the weight-distribution bound, a lower bound on the cardinality of support of an eigenfunction of a distance-regular ...
Goryainov, Sergey, +3 more
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Combinatorial designs with two singular values II. Partial geometric designs [PDF]
, 2005 In this and an earlier paper [E.R. van Dam, E. Spence, Combinatorial designs with two singular values. I. Uniform multiplicative designs, J. Combin.
Spence, E. +3 more
core +2 more sources