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A Benchmark Set of Bioactive Molecules for Diversity Analysis of Compound Libraries and Combinatorial Chemical Spaces. [PDF]

J Chem Inf Model
Neumann A, Klein R.
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Rational design and combinatorial chemistry of ionizable lipids for RNA delivery.

Journal of materials chemistry. B, 2023
In 2018, LNPs enabled the first FDA approval of a siRNA drug (Onpattro); two years later, two SARS-CoV-2 vaccines (Comirnaty, Spikevax) based on LNPs containing mRNA also arrived at the clinic, saving millions of lives during the COVID-19 pandemic ...
Yue Xu, Alex Golubovic, Shufen Xu, Annia Pan, Bowen Li   +4 more
semanticscholar   +1 more source

Combinatorial Carbohydrate Chemistry

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lisa A. Marcaurelle, Peter H. Seeberger
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Dynamic combinatorial chemistry

Drug Discovery Today, 2002
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional ...
Jeremy K. M. Sanders, Ricardo L. E. Furlan, Sijbren Otto   +2 more
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Combinatorial chemistry of hydantoins

Bioorganic & Medicinal Chemistry Letters, 1998
Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.
Astrid Boeijen, John A. W. Kruijtzer, Rob M. J. Liskamp   +2 more
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Dynamic Generation of G-Quadruplex DNA Ligands by Target-Guided Combinatorial Chemistry on a Magnetic Nanoplatform.

Journal of Medicinal Chemistry, 2018
Dynamic combinatorial chemistry (DCC) has emerged as a promising strategy for template-driven selection of high-affinity ligands for biological targets from equilibrating combinatorial libraries.
S. Jana, Deepanjan Panda, P. Saha, G. Pantoș, J. Dash   +4 more
semanticscholar   +1 more source

Steroids and Combinatorial Chemistry

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Liviu C. Ciobanu, Donald Poirier, Martin R. Tremblay, René Maltais   +3 more
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Basics of Combinatorial Chemistry

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Alain Wagner, Cécile Vanier
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Overview of Combinatorial Chemistry

Current Protocols in Pharmacology, 2000
AbstractThis unit provides an overview of combinatorial chemistry, including the design and construction of combinatorial libraries for drug discovery. Strategies and resources for library synthesis are summarized, and examples of combinatorial libraries are given.
Stephen L. Crooks, Leslie J. Charles
openaire   +3 more sources