Results 141 to 150 of about 7,603,109 (259)

Combinatorial chemistry

, 1994
An overview of combinatorial chemistry is presented. Combinatorial chemistry, sometimes referred to as `irrational drug design,' involves the generation of molecular diversity.
Nielsen, John
core  

Protein-protein interaction inhibitors in the human proteome: lessons from 117 targeted interactions. [PDF]

RSC Med Chem
Hyde EE, Beekman AM.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular LEGION: incalculably large coverage of chemical space around the NLRP3 target. [PDF]

Sci Data
Zagribelnyy B, Aladinskiy V, Bondarev N, Ilin I, Malkov M, Vasileva A, Ding X, Lin A, Shayakhmetov R, Aliper A, Ren F, Zhavoronkov A.   +11 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

On-chip electrocatalytic microcells for high-throughput experimentation of electrocatalysts. [PDF]

iScience
Liu Z, Tao J, Ou G, Cao R, Liu C, Jiang L.   +5 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

The (r)evolution of chemical space and molecular modeling: a time-resolved perspective. [PDF]

J Comput Aided Mol Des
Del Moral-Morales A, Feitosa FL, Andrade CH, Medina-Franco JL.   +3 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Proteoform Detection Across 17,000 Single Nuclei From Differentiating Skin Keratinocytes. [PDF]

Mol Cell Proteomics
Kanchustambham VL, Pla I, Xu T, Su P, Fisher NP, Hollas MAR, Markiv P, Agarwal U, Lysakowska M, Kafader JO, Bao X, Kelleher NL.   +11 more
europepmc   +1 more source