Results 281 to 290 of about 436,297 (318)

Discovery of novel phosphors for use in light emitting diodes using heuristics optimization-assisted combinatorial chemistry

, 2012
Non-dominated sorting genetic algorithm (NSGA) and particle swarm optimization (PSO), the most well-known population-based heuristics optimization techniques, were used along with high-throughput synthesis and a characterization technique to discover a ...
Kyung Hyun Son, S. Singh, K. Sohn
semanticscholar   +1 more source

Parallel personal comments on "classical" papers in combinatorial chemistry.

Journal of combinatorial chemistry, 1999
It is appropriate to start this new journal with an article about the history of this particular fieldsespecially when the field is so new that even the basic terminology is not completely defined.† When I was asked to write an article about the history ...
M. Lebl
semanticscholar   +1 more source

Combinatorial Chemistry-Challenge and Chance for the Development of New Catalysts and Materials.

Angewandte Chemie, 1999
One should not underestimate the capability of the combinatorial method in solid-state chemistry; this is the opinion of the author. Combinatorial chemistry can provide a large number of new compounds, but once the components that are interesting for a ...
W. Maier
semanticscholar   +1 more source

The contribution of combinatorial chemistry to lead generation: an interim analysis.

Current Medicinal Chemistry, 2001
In the process of finding new drug candidates medicinal chemists nowadays have a variety of options to choose from, one is to apply combinatorial chemistry techniques.
A. Adang, P. Hermkens
semanticscholar   +1 more source

Mass spectrometry and combinatorial chemistry: a short outline.

Journal of Mass Spectrometry, 2001
The rapid evolution of combinatorial chemistry in recent years has led to a dramatic improvement in synthetic capabilities. The goal is to accelerate the discovery of molecules showing affinity against a target, such as an enzyme or a receptor, through ...
A. Triolo, M. Altamura, F. Cardinali, A. Sisto, C. Maggi   +4 more
semanticscholar   +1 more source

Recent advances in combinatorial chemistry applied to development of anti-HIV drugs.

Mini-Reviews in Medical Chemistry, 2006
A compilation of combinatorial chemistry techniques applied to anti-HIV drug development is presented in this review. This synthetic strategy together with high throughput screening assays has allowed the discovery and optimization of novel lead anti-HIV
S. Pettersson, I. Clotet-Codina, J. Esté, J. Borrell, J. Teixidó   +4 more
semanticscholar   +1 more source

Combinatorial Library-Screened Array for Rapid Clinical Sperm Quality Assessment.

Analytical Chemistry
Nonspecific interactions are ubiquitous and important in biology; however, they are rarely valued or employed in the field of clinical disease diagnosis.
Hui Huang, Xiao Shi, Weiwei Ni, Wenhui Zhang, Ligong Ji, Jin Wu, Zhenwei Yuan, Yanlin Ma, Callum Stewart, K. L. Fok, Linxian Li, Jinsong Han   +11 more
semanticscholar   +1 more source

Structural Unit Analysis Identifies Lead Series and Facilitates Scaffold Hopping in Combinatorial Chemistry

Journal of Chemical Information and Modeling, 2006
Combinatorial chemistry and high-throughput screening technologies produce huge amounts of data on a regular basis. Sieving through these libraries of compounds and their associated assay data to identify appropriate series for follow-up is a daunting ...
Philippa R. N. Wolohan, L. Akella, Roman J. Dorfman, P. Nell, S. Mundt, R. Clark   +5 more
semanticscholar   +1 more source

HPLC/NMR in Combinatorial Chemistry

, 1998
When sufficient material is available, NMR spectroscopy is unsurpassed for detailed structure determination in solution. However, the application of NMR to the determination of structure in multicomponent organic chemical systems prior to physical ...
J. Chin, Jay B. Fell, M. Jarosinski, M. Shapiro, J. Wareing   +4 more
semanticscholar   +1 more source

Solution phase combinatorial chemistry.

Combinatorial chemistry & high throughput screening, 1998
Combinatorial chemistry and parallel array synthesis techniques are now used extensively in the drug discovery process. Although published literature has been dominated by solid phase chemistry approaches, the use of solution phase techniques has also ...
A. Merritt
semanticscholar   +1 more source