Results 71 to 80 of about 1,745,964 (294)
Haematologica, 2020 Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. However, recent studies have shown that the
Simon Hultmark +12 more
doaj +1 more source
Combinatorial complexity of signed discs
Computational Geometry, 1995 Let $CC^+$ and $CC^-$ be two collections of topological discs of arbitrary radii. The collection of discs is `topological' in the sense that their boundaries are Jordan curves and each pair of Jordan curves intersect at most twice. We prove that the region $cupCC^+ -cupCC^-$ has combinatorial complexity at most $10n-30$ where $p=|CC^+|$, $q=|CC^-|$ and
Diane L. Souvaine, Chee-Keng Yap
openaire +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A Topological Characterization to Arbitrary Resilient Asynchronous Complexity
Mathematics, 2022 In this work, we extend the topology-based framework and method for the quantification and classification of general resilient asynchronous complexity.
Yunguang Yue +3 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Lexicographic Unranking of Combinations Revisited
Algorithms, 2021 In the context of combinatorial sampling, the so-called “unranking method” can be seen as a link between a total order over the objects and an effective way to construct an object of given rank.
Antoine Genitrini, Martin Pépin
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Case-based complexity: within-case time variation and temporal casing
, 2021 We observe that time is central to most social dynamics and yet remains poorly understood. The complexity sciences have contributed a wide range of concepts and tools to investigate and recast time in social systems.
Chang, Robin +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source