Results 121 to 130 of about 610,031 (298)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Combinatorial Identities for Incomplete Tribonacci Polynomials [PDF]
, 2014 The incomplete tribonacci polynomials, denoted by Tn(s)(x), generalize the usual tribonacci polynomials Tn (x) and have been shown to satisfy several algebraic identities.
Mark Shattuck, Shattuck, Mark
core +1 more source
Le Matematiche, 1996 We specialise an ingeniously contrived identity to obtain a plethora of startling combinatorial identities. Limiting cases include well known evaluations of ζ(2), ζ(4) and ζ(6).
Chu Wenchang
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Matrix bids in combinatorial auctions: expressiveness and micro-economic properties [PDF]
A combinatorial auction is an auction where multiple items are for sale simultaneously to a set of buyers. Furthermore, buyers are allowed to place bids on subsets of the available items.
Spieksma, F.C.R. +2 more
core
On Type 2 Degenerate Poly-Frobenius-Euler Polynomials
Recoletos Multidisciplinary Research JournalBackground: This paper introduces a class of special polynomials called Type 2 degenerate poly-Frobenius-Euler polynomials, defined using the polyexponential function. Motivated by the expanding theory of degenerate versions of classical polynomials, the
Roberto B. Corcino +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Combinatorial Interpretations of Fibonomial Identities [PDF]
, 2011 The Fibonomial numbers are defined by \[ \begin{bmatrix}n \\ k \end{bmatrix} = \frac{\prod_{i=n-k+1} ^{n} F_i}{\prod_{j=1}^{k} F_j} \] where $F_i$ is the $i$th Fibonacci number, defined by the recurrence $F_n=F_{n-1}+F_{n-2}$ with initial conditions ...
Reiland, Elizabeth
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source