Results 241 to 250 of about 610,380 (297)

The Scaling Limit of Random Two-Connected Series-Parallel Maps. [PDF]

J Theor Probab
Amankwah D, Björnberg J, Stefánsson SÖ, Stufler B, Turunen J.   +4 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Hidden gradients before form: a spatial transcriptomic atlas of wheat spike patterning. [PDF]

Plant Cell
Jhu MY, Lee TA.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Epistasis and background dependence in the evolution of Omicron variants of the SARS-CoV-2 spike protein. [PDF]

Mol Biol Evol
Moulana A, Dupic T, Desai MM.
europepmc   +1 more source

Astrocyte heterogeneity in the neocortex: developmental origins, molecular diversity, and functional implications. [PDF]

Front Cell Dev Biol
Zhou J, Bocchi R.
europepmc   +1 more source

Yield Smarter, Not Harder: Good Practices for Machine Learning of Reaction Outcomes. [PDF]

J Am Chem Soc
Ismail I, Landrum GA, Riniker S.
europepmc   +1 more source

Cover-free families on hypergraphs and combinatorial group testing. [PDF]

J Comb Optim
Idalino TB, Moura L.
europepmc   +1 more source

Regulatory logic of neuronal differentiation in the <i>Drosophila</i> visual system. [PDF]

Proc Natl Acad Sci U S A
Treese M, Chen YC, Tyree A, Coyne R, Lake C, Tabi OB, Rajesh R, Chen YD, Hassan H, Li H, Desplan C, Özel MN.   +11 more
europepmc   +1 more source