Results 221 to 230 of about 171,184 (277)

An expanded role for single-cell chemical genomics profiling in drug discovery. [PDF]

Biochem J
Wyatt A, Hoffer-Hawlik K, Giglio RM, Azizi E, McFaline-Figueroa JL.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

4-Phenylbut-2-yl Esters from the Essential Oil of <i>Artemisia rutifolia</i> from Mongolia. [PDF]

Molecules
Irrera E, Ahn YJ, Sandui S, Shatar A, Baldovini N.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Phylogeny-guided discovery of a promiscuous P450 macrocyclase for the production of diverse atropopeptides. [PDF]

Chem Sci
Tan B, Breunig P, Arbib L, Kakumu Y, Biermann F, Hardes K, Hefendehl J, Helfrich EJN.   +7 more
europepmc   +1 more source

Versatile use of chimpanzee call combinations promotes meaning expansion. [PDF]

Sci Adv
Girard-Buttoz C, Neumann C, Bortolato T, Zaccarella E, Friederici AD, Wittig RM, Crockford C.   +6 more
europepmc   +1 more source

Regulatory Variants in the KRAS 3'UTR and Intron 2 Are Associated with Breast Cancer Susceptibility Through Independent and Combinatorial Effects in a Mexican Population. [PDF]

Biomedicines
Garibaldi-Ríos AF, Figuera LE, Gómez-Meda BC, Zúñiga-González GM, Dávalos-Rodríguez IP, García-Verdín PM, Puebla-Pérez AM, Carrillo-Dávila IA, Gallegos-Arreola MP.   +8 more
europepmc   +1 more source

High-throughput combinatorial screening of antiplatelet drugs for personalized medicine. [PDF]

Microsyst Nanoeng
Wang C, Zhu W, Zhu J, Gao T, Jiang Z, Zhang T, Chen L, Zhang J, Liu Y, Chang ACY.   +9 more
europepmc   +1 more source

Factorization norms and an inverse theorem for MaxCut. [PDF]

Math Ann
Balla I, Hambardzumyan L, Tomon I.
europepmc   +1 more source