Results 141 to 150 of about 8,069,229 (248)

Adaptive approach heuristics for the generalized assignment problem [PDF]

The Generalized Assignment Problem consists in assigning a set of tasks to a set of agents with minimum cost. Each agent has a limited amount of a single resource and each task must be assigned to one and only one agent, requiring a certain amount of the
Helena Ramalhinho-Lourenço, Daniel Serra   +1 more
core  

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Minimum evolution molecular clock: quantum annealing for guide tree construction in multiple sequence alignment. [PDF]

BMC Bioinformatics
Park Y, Kim J, Huh J.
europepmc   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Machine learning-assisted high-speed combinatorial optimization with Ising machines for dynamically changing problems. [PDF]

Nat Commun
Hamakawa Y, Kashimata T, Yamasaki M, Tatsumura K.   +3 more
europepmc   +1 more source

A Discrete Particle Swarm Optimization Algorithm for Bi-Criteria Warehouse Location Problem [PDF]

The uncapacitated warehouse location problem (UWLP) is one of the widely studied discrete location problems, in which the nodes (customers) are connected to a number (w) of warehouses in such a way that the total cost, yields from the dissimilarities ...
Tugba Sarac, Fehmi Burcin Ozsoydan
core  

Methanesulfonic Acid as a Dual‐Role Reagent for Porous Polymer Network Design

Advanced Materials, EarlyView.
The design of porous polymer networks (PPNs) using methanesulfonic acid (MSA) as a dual‐role reagent facilitates the synthesis of robust PPNs for specific applications. It also makes the scale‐up process techno‐economically feasible because MSA functions simultaneously as both a solvent and a catalyst for the reaction.
Kelechi Festus, Arnab Ghosh, Ankit Mondal, Theresa Ariri, Suman Mandal, Ahana Sarkar, Urme Podder, Qingsheng Wang, Hong‐Cai Zhou   +8 more
wiley   +1 more source

Breaking Bottlenecks in Solid Electrolyte Discovery With Large Artificial Intelligence Models

Advanced Materials, EarlyView.
Large AI models are presented as a route to break key bottlenecks in solid electrolyte discovery by linking materials databases, machine‐learning interatomic potentials, large language models, and autonomous experiments. This perspective highlights how AI can accelerate the identification of solid electrolytes with fast ion transport, stable interfaces,
Eric Jianfeng Cheng, Min Hong, Zhiquan Zeng, Chuanyu Liu, Qian Wang, Melissa Jane Meadowcroft, Vlad Badilita, Carlos Miguel Costa, Senentxu Lanceros‐Méndez, Ying Li, Chenyao Ma, Weibo Gong, Surendra Kumar Martha, Aloysius Soon, Piao Ma, Di Zhang, Teguh Ariyanto, Sudaryanto, Hiroshi Kakinuma, Jie Zhao, Jiayu Peng, Pengfei Ou, Jun Lu, Shin‐ichi Orimo, Hao Li   +24 more
wiley   +1 more source

Phylogenetic inference under the balanced minimum evolution criterion via semidefinite programming. [PDF]

Bioinformatics
Skums P.
europepmc   +1 more source

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source