Results 61 to 70 of about 167,714 (331)

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

A Hybrid Particle Swarm Optimization with Genetic Operator for Vehicle Routing Problem

open access: yesJournal of Advances in Information Technology, 2010
The Vehicle Routing Problem (VRP) is a NP-hard and Combinatorial optimization problem. Combinatorial optimization problem can be viewed as searching for best element in a set of discrete items, which can be solved using search algorithm or meta heuristic.
Geetha Shanmugam   +2 more
doaj   +1 more source

A Computational Study of Genetic Crossover Operators for Multi-Objective Vehicle Routing Problem with Soft Time Windows [PDF]

open access: yes, 2008
The article describes an investigation of the effectiveness of genetic algorithms for multi-objective combinatorial optimization (MOCO) by presenting an application for the vehicle routing problem with soft time windows.
Geiger, Martin Josef
core   +1 more source

Weld sequence optimization: the use of surrogate models for solving sequential combinatorial problems

open access: yes, 2005
The solution of combinatorial optimization problems usually involves the consideration of many possible design configurations. This often makes such approaches computationally expensive, especially when dealing with complex finite element models.
Bhaskar, A.   +3 more
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Trip Planning Based on subQUBO Annealing

open access: yesIEEE Access, 2023
The trip planning problem (TPP) can be formulated as a combinatorial optimization problem that searches for the best route to visit a series of landmarks and hotels.
Tatsuya Noguchi   +3 more
doaj   +1 more source

Submodular Minimization Under Congruency Constraints

open access: yes, 2018
Submodular function minimization (SFM) is a fundamental and efficiently solvable problem class in combinatorial optimization with a multitude of applications in various fields.
Nägele, Martin   +2 more
core   +1 more source

Dominance rules in combinatorial optimization problems [PDF]

open access: yesEuropean Journal of Operational Research, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Antoine Jouglet, Jacques Carlier
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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