Results 161 to 170 of about 10,899,248 (403)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effects of a combined supercritical extraction/thermal cycle on binder removal cycle time, yield, residual carbon, and defect formation in multilayer ceramic capacitors [PDF]

, 2010
Brandon Abeln
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Investigation of a Hybridized Cascade Trigeneration Cycle Combined with a District Heating and Air Conditioning System Using Vapour Absorption Refrigeration Cooling: Energy and Exergy Assessments

Energies
The insufficiency of energy supply and availability remains a significant global energy challenge. This work proposes a novel approach to addressing global energy challenges by testing the supercritical property and conversion of low-temperature thermal ...
Larry Orobome Agberegha, Peter Alenoghena Aigba, Solomon Chuka Nwigbo, Francis Onoroh, Olusegun David Samuel, Tanko Bako, Oguzhan Der, Ali Ercetin, Ramazan Sener   +8 more
doaj   +1 more source

Combined cycle energy production [PDF]

, 2008
Muntyan, Andriy
openaire   +3 more sources

Combined Cycles for Reusable and Cost-Efficient Space Flight [PDF]

, 2023
Mason Roddy
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Exergy-Based Analysis and Optimization of an Integrated Solar Combined-Cycle Power Plant. [PDF]

Entropy (Basel), 2020
Elmorsy L, Morosuk T, Tsatsaronis G.
europepmc   +1 more source

Degradation Law and Service Life Prediction Model of Tunnel Lining Concrete Suffered Combined Effects of Sulfate Attack and Drying–Wetting Cycles [PDF]

, 2022
Feng Lu, Haiyan Wang, Lichuan Wang, Kai Zhao, Junru Zhang   +4 more
openalex   +1 more source

Performance and operational economics estimates for a coal gasification combined-cycle cogeneration powerplant [PDF]

A performance and operational economics analysis is presented for an integrated-gasifier, combined-cycle (IGCC) system to meet the steam and baseload electrical requirements.
Burns, R. K., Easley, A. J., Nainiger, J. J.   +2 more
core   +1 more source