Results 281 to 290 of about 10,899,248 (403)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Combinational BET and mTOR inhibition unveils EGR1 as acute myeloid leukemia prognostic biomarker. [PDF]

Sci Rep
Latancia MT, Silva WFD, Bragança-Jardim E, Terra FF, Asprino PF, Pereira WO, Buzatto VC, Galante PA, Inoue LT, Fonseca AR, Kimmemgs TN, Arrais-Rodrigues C, Rocha V, Novis Y, Camara NOS, Lepique AP, Reis LFL, Amano MT.   +17 more
europepmc   +1 more source

Effects of cycle peak temperature ratio on the performance of combined cycle power plant

, 2016
Thamir K. Ibrahim, M. M. Rahman
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Quantitative assessment of changes in left ventricular myocardial work and energy loss in HER2-positive breast cancer patients undergoing combination therapy with chemotherapy and targeted treatment using pressure-strain loop and vector flow mapping. [PDF]

Quant Imaging Med Surg
Chen R, Qin W, Chen C, Guo X, Huang L, Liu K, Shi W, Zhang C, Dong S, Lu G.   +9 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells. [PDF]

Cancer Metab
Nishikubo K, Ohgaki R, Okanishi H, Xu M, Kanai Y.   +4 more
europepmc   +1 more source

Blackout Recovery Scenario in a Combined-Cycle Power Plant via Line Charging and Internal Cross-Supply: A Techno-Economic Comparative Analysis

Gamal Fiqih Handono Warih, Fauzan Hanif Jufri, Muhammad Gillfran Samual, Chairul Hudaya   +3 more
openalex   +1 more source

Exergoeconomic analysis and determination of power cost in MCFC – steam turbine combined cycle

, 2019
Fellipe Sartori da Silva, José Alexandre Matelli   +1 more
openalex   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source