Results 91 to 100 of about 659,807 (312)

Improved Design Formulae for Buckling of Orthotropic Plates under Combined Loading [PDF]

open access: yes, 2008
Simple, accurate buckling interaction formulae are presented for long orthotropic plates with either simply supported or clamped longitudinal edges and under combined loading that are suitable for design studies.
Nemeth, Michael P., Weaver, Paul M.
core   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Nonlinear analyses of composite aerospace structures in sonic fatigue [PDF]

open access: yes
The primary research effort of this project is the development of analytical methods for the prediction of nonlinear random response of composite aerospace structures subjected to combined acoustic and thermal loads.
Mei, Chuh
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Aeroelastic modeling for the FIT team F/A-18 simulation [PDF]

open access: yes
Some details of the aeroelastic modeling of the F/A-18 aircraft done for the Functional Integration Technology (FIT) team's research in integrated dynamics modeling and how these are combined with the FIT team's integrated dynamics model are described ...
Wieseman, Carol D., Zeiler, Thomas A.
core   +1 more source

Monitoring voltage collapse margin by measuring the area voltage across several transmission lines with synchrophasors

open access: yes, 2014
We consider the fast monitoring of voltage collapse margin using synchrophasor measurements at both ends of transmission lines that transfer power from two generators to two loads.
Dobson, Ian, Ramirez, Lina
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Method for the Combination of Stochastic Time Varying Load Effects [PDF]

open access: yes, 1983
The problem of evaluating the probability that a structure becomes unsafe under a combination of loads, over a given time period, is addressed. The loads and load effects are modeled as either pulse (static problem) processes with random occurrence ...
Pearce, H.T., Wen, Y.K.
core  

Integrating power flow modelling with building simulation [PDF]

open access: yes, 2001
The inclusion of photovoltaic facades and other local sources of both heat and power within building designs has given rise to the concept of embedded generation: where some or all of the heat and power demands are produced close to the point of use ...
Clarke, J.A., Kelly, N.J.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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