Results 91 to 100 of about 133,362 (265)
Zhongguo Jianchuan YanjiuObjectiveIn order to find a numerical simulation method that can simulate the combined effects of multi-damage loads under cabin internal explosion, while considering both simulation accuracy and efficiency, this paper proposes two high-efficiency ...
Zhenhao WU +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Verifying a Glass Pane Under Combined In-Plane Compression and Out-of-Plane Lateral Loads
Challenging Glass Conference ProceedingsUsing glass elements as designated members of the structural design of buildings does not only require conscientious planning of structural redundancies, but also proof of safety for single components.
Philipp Kießlich +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Analysis of edge stress of combined shell under internal waves
AIP AdvancesInternal wave is essentially a gravity wave induced by the layered structure of water (e.g., density stable layering), with its maximum amplitude occurring within the ocean.
Yiqiong Cui
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Multi-Parameter Perturbation Solution for Functionally Graded Piezoelectric Cantilever Beams under Combined Loads. [PDF]
Materials (Basel), 2018 Lian Y +5 more
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Combined effects of thermal stress and ice impacts on polar ship hulls: A numerical study
Applied Ocean ResearchIn polar environments, the combined effects of low temperatures and ice loads greatly influence the structural response of ships. While existing studies have primarily focused on individual factors, systematic analysis of their combined effects is ...
Hegang Ji +5 more
doaj +1 more source