Results 161 to 170 of about 3,352,860 (301)

Human In Vivo Validation of Frequency-Dependent QTI. [PDF]

Magn Reson Med
Niesen S, Veldmann M, Ajouz A, Stöcker T.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Organization and employment of attack helicopters: final report.

, 2002
The purpose of this study is to establish a US Army Training and Doctrine Command (TRADOC) concept for the employment of the attack helicopter and to determine the proponents for attack helicopter organizations.
United States Army, Combined Arms Center (Provisional)
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

QUALITY METRICS FOR IT PROJECT MANAGEMENT [PDF]

Using metrics and indicators for the evaluation of the IT projects management have the advantage of providing rigorous details about the required effort and the boundaries of the IT deliverables. There are some disadvantages, as well, due to the fact the
Radu MARSANU, Paul POCATILU, Felician ALECU   +2 more
core  

Automated CTA-Derived Collateral Grading and Morphologic Metrics for Enhanced Prediction of Poststroke Outcomes. [PDF]

AJNR Am J Neuroradiol
Deshpande A, Wang J, Bochenek KM, Oliverio P, Altaweel L, Yi S, Bahiru Z, Moro D, Heinzelmann GK, Tahsili-Fahadan P, Laksari K.   +10 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Using Neural Networks In Software Metrics [PDF]

Software metrics provide effective methods for characterizing software. Metrics have traditionally been composed through the definition of an equation, but this approach is limited by the fact that all the interrelationships among all the parameters be ...
Nicolae Begnescu, Ion I. Bucur
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Fast fourier transform based spectral features for machine learning prediction of gamma passing rates in virtual VMAT PSQA: A feasibility study. [PDF]

J Appl Clin Med Phys
Yan B, Peng H, Xue X, Zheng C, Wu A.
europepmc   +1 more source