Results 71 to 80 of about 662,647 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Selected Options for Modelling of Transport Processes Particularly in Relation to Intermodal Transport

open access: yesMATEC Web of Conferences, 2017
The first specialized road-rail combined transport operators were founded by road hauliers, who experienced road capacity bottlenecks and collaborating railways in the late 1960s in Europe.
Gnap Jozef, Kubáňová Jaroslava
doaj   +1 more source

Development of mining operations in deep quarries using automobile and combined transport [PDF]

open access: yesE3S Web of Conferences
Aim of this paper is to explore the development of mining operations in deep quarries utilizing automobile and combined transport systems to overcome these challenges.
Komilov S.   +4 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Comparison of Operational and Economic Aspects of Direct Road Transport and Continental Combined Transport

open access: yesCommunications, 2017
The aim of this paper is to compare economic and operational aspects in the transition from direct road transport to unaccompanied CT using intermodal road semitrailers.
Jaromir Siroky   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

RECOMMENDATIONS FOR THE SUPPORT OF THE INTERMODAL TRANSPORT DEVELOPMENT IN THE SLOVAK REPUBLIC

open access: yesPerner’s Contacts, 2011
The paper deals with an characteristics of the current state support in the area of the intermodal transport development and it also presents recommendations for the additional support of the intermodal transport development in Slovakia.
Ondřej Stopka, Marián Šulgan
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Multimodal and Intermodal Transportation Systems

open access: yesCommunications, 2016
The aim of this paper is to provide information on the general characterization of multimodal transport, intermodal and combined transport. There is also mentioned the distribution of basic transport processes and types of transhipment.
Jaroslava Kubanova, Conrad Schmidt
doaj   +1 more source

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