Results 111 to 120 of about 291,896 (358)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Spectroscopic Observations of New Oort Cloud Comet 2006 VZ13 and Four Other Comets [PDF]

, 2009
Spectral data are presented for comets 2006 VZ13 (LINEAR), 2006 K4 (NEAT), 2006 OF2 (Broughton), 2P/Encke, and 93P/Lovas I, obtained with the Cerro-Tololo Inter-American Observatory 1.5-m telescope in August 2007.
A. M. Gilbert, Arvesen, A’Hearn, A’Hearn, Cochran, Cochran, Cochran, E. Unda-Sanzana, Fink, Fink, Fink, Haser, Newburn, O. Vaduvescu, P. A. Wiegert, Sposetti, Storrs, Tatum, Tody   +18 more
core   +1 more source

Organics in comet 67P – a first comparative analysis of mass spectra from ROSINA–DFMS, COSAC and Ptolemy

, 2017
The ESA Rosetta spacecraft followed comet 67P at a close distance for more than 2 yr. In addition, it deployed the lander Philae on to the surface of the comet.
K. Altwegg, H. Balsiger, J. Berthelier, A. Bieler, U. Calmonte, S. Fuselier, F. Goesmann, S. Gasc, T. Gombosi, L. L. Roy, J. Keyser, A. Morse, M. Rubin, M. Schuhmann, Matthew Taylor, C. Tzou, I. Wright   +16 more
semanticscholar   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

Evaluating In Vitro DNA Damage Using Comet Assay.

Journal of Visualized Experiments, 2017
DNA damage is a common phenomenon for each cell during its lifespan, and is defined as an alteration of the chemical structure of genomic DNA. Cancer therapies, such as radio- and chemotherapy, introduce enormous amount of additional DNA damage, leading ...
Yanxin Lu, Yang Liu, Chunzhang Yang
semanticscholar   +1 more source

Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis‐Mediated DNA Repair in Osteosarcoma

Advanced Science, EarlyView.
The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang, Zhaohui Li, Lina Tang, Zhen Pan, Xiang Fei, Chen Tan, Aina He, Qingcheng Yang, Dongdong Cheng   +8 more
wiley   +1 more source

Measuring DNA modifications with the comet assay: a compendium of protocols

Nature Protocols, 2023
A. Collins, P. Møller, G. Gajski, Sona Vodenkova, Abdulhadi Abdulwahed, Diana Anderson, E. Bankoglu, S. Bonassi, É. Boutet-Robinet, G. Brunborg, Christy Chao, M. Cooke, C. Costa, S. Costa, A. Dhawan, J. de Lapuente, C. Bo’, Julien Dubus, M. Dusinska, S. Duthie, N. Yamani, B. Engelward, I. Gaivão, L. Giovannelli, R. Godschalk, S. Guilherme, K. Gutzkow, K. Habas, Alba Hernández, Ó. Herrero, M. Isidori, A. Jha, S. Knasmüller, I. Kooter, G. Koppen, M. Kruszewski, C. Ladeira, B. Laffon, M. Larramendy, L. Hégarat, A. Lewies, A. Lewińska, G. E. Liwszyc, A. D. de Ceráin, M. Manjanatha, R. Marcos, M. Milić, V. M. de Andrade, M. Moretti, D. Muruzabal, M. Novak, Rui Oliveira, A. Olsen, Norah A Owiti, Mário Pacheco, A. Pandey, S. Pfuhler, B. Pourrut, K. Reisinger, E. Rojas, E. Rundén-Pran, J. Sanz-Serrano, Sergey Shaposhnikov, V. Sipinen, K. Smeets, H. Stopper, J. Teixeira, V. Valdiglesias, M. Valverde, Frédérique van Acker, F. V. van Schooten, Marie Z. Vasquez, Johannes F. Wentzel, M. Wnuk, Annelies Wouters, B. Žegura, T. Zikmund, S. Langie, A. Azqueta   +78 more
semanticscholar   +1 more source

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Review of cometary spectra [PDF]

The spectra of comet Kohoutek, comet Bradfield, and comet Mrkos are reviewed and compared in relation to stellar spectroscopy and evolution. The possibility of observing the absorption spectrum of a comet and direct measurement of Doppler shifts due to ...
Herbig, G. H.
core   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source