Results 141 to 150 of about 225,144 (339)
ICE telemetry performance [PDF]
Acquiring telemetry data from the International Cometary Explorer (ICE) at its encounter with the comet Giacobini-Zinner on September 11, 1985 proved to be among the more difficult challenges the DSN has met in recent years.Layland, J. W.core +1 more sourceInterpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting
Environmental and Molecular Mutagenesis, EarlyView.Abstract
Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White +14 morewiley +1 more sourceSeverity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)
Environmental and Molecular Mutagenesis, EarlyView.Abstract
Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White +17 morewiley +1 more sourceThe Comet Interceptor Mission
Space Science ReviewsAbstractHere we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What Jones Geraint H., Snodgrass Colin, Tubiana Cecilia, Küppers Michael, Kawakita Hideyo, Lara Luisa M., Agarwal Jessica, André Nicolas, Attree Nicholas, Auster Uli, Bagnulo Stefano, Bannister Michele, Beth Arnaud, Bowles Neil, Coates Andrew, Colangeli Luigi, Corral van , Damme Carlos, Da Deppo Vania, De Keyser Johan, Della Corte Vincenzo, Edberg Niklas, El-Maarry Mohamed Ramy, Faggi Sara, Fulle Marco, Funase Ryu, Galand Marina, Goetz Charlotte, Groussin Olivier, Guilbert-Lepoutre Aurélie, Henri Pierre, Kasahara Satoshi, Kereszturi Akos, Kidger Mark, Knight Matthew, Kokotanekova Rosita, Kolmasova Ivana, Kossacki Konrad. Kührt Ekkehard, Kwon Yuna, La Forgia Fiorangela, Levasseur-Regourd Anny-Chantal, Lippi Manuela, Longobardo Andrea, Marschall Raphael, Morawski Marek, Muñoz Olga, Näsilä Antti, Nilsson Hans, Opitom Cyrielle, Pajusalu Mihkel, Pommerol Antoine, Prech Lubomir, Rando Nicola, Ratti Francesco, Rothkaehl Hanna, Rotundi Alessandra, Rubin Martin, Sakatani Naoya, Sánchez Joan Pau, Simon Wedlund Cyril, Stankov Anamarija, Thomas Nicolas, Toth Imre, Villanueva Geronimo, Vincent Jean-Baptiste, Volwerk Martin, Wurz Peter, Wielders Arno, Yoshioka Kazuo, Aleksiejuk Konrad, Alvarez Fernando, Amoros Carine, Aslam Shahid, Atamaniuk Barbara, Baran Jędrzej, Barciński Tomasz, Beck Thomas, Behnke Thomas, Berglund Martin, Bertini Ivano, Bieda Marcin, Binczyk Piotr, Busch Martin-Diego, Cacovean Andrei, Capria Maria Teresa, Carr Chris, Castro Marín José María, Ceriotti Matteo, Chioetto Paolo, Chuchra-Konrad Agata, Cocola Lorenzo, Colin Fabrice, Crews Chiaki, Cripps Victoria, Cupido Emanuele, Dassatti Alberto, Davidsson Björn J. R., De Roche Thierry, Deca Jan, Del Togno Simone, Dhooghe Frederik, Donaldson Hanna Kerri, Eriksson Anders, Fedorov Andrey, Fernández-Valenzuela Estela, Ferretti Stefano, Floriot Johan, Frassetto Fabio, Fredriksson Jesper, Garnier Philippe, Gaweł Dorota, Génot Vincent, Gerber Thomas, Glassmeier Karl-Heinz, Granvik Mikael, Grison Benjamin, Gunell Herbert, Hachemi Tedjani, Hagen Christian, Hajra Rajkumar, Harada Yuki, Hasiba Johann, Haslebacher Nico, Herranz De , La , Revilla Miguel Luis, Hestroffer Daniel, Hewagama Tilak, Holt Carrie, Hviid Stubbe, Iakubivskyi Iaroslav, Inno Laura, Irwin Patrick, Ivanovski Stavro, Jansky Jiri, Jernej Irmgard, Jeszenszky Harald, Jimenéz Jaime, Jorda Laurent, Kama Mihkel, Kameda Shingo, Kelley Michael S. P., Klepacki Kamil, Kohout Tomáš, Kojima Hirotsugu, Kowalski Tomasz, Kuwabara Masaki, Ladno Michal, Laky Gunter, Lammer Helmut, Lan Radek, Lavraud Benoit, Lazzarin Monica, Le Duff Olivier, Lee Qiu-Mei, Lesniak Cezary, Lewis Zoe, Lin Zhong-Yi, Lister Tim, Lowry Stephen, Magnes Werner, Markkanen Johannes, Martinez Navajas Ignacio, Martins Zita, Matsuoka Ayako, Matyjasiak Barbara, Mazelle Christian, Mazzotta , Epifani Elena, Meier Mirko, Michaelis Harald, Micheli Marco, Migliorini Alessandra, Millet Aude-Lyse, Moreno Fernando, Mottola Stefano, Moutounaick Bruno, Muinonen Karri, Müller Daniel R., Murakami Go, Murata Naofumi, Myszka Kamil, Nakajima Shintaro, Nemeth Zoltan, Nikolajev Artiom, Nordera Simone, Ohlsson Dan, Olesk Aire, Ottacher Harald, Ozaki Naoya, Oziol Christophe, Patel Manish, Savio Paul Aditya, Penttilä Antti, Pernechele Claudio, Peterson Joakim, Petraglio Enrico, Piccirillo Alice Maria, Plaschke Ferdinand, Polak Szymon, Postberg Frank, Protopapa Silvia, Ranvier Sylvain, Raymond Sean, Richter Ingo, Rigamonti Roberto, Ruiz Rodriguez Irene, Santolik Ondrej, Sasaki Takahiro, Shirley Katherine, Slavinskis Andris, Soucek Jan, Stephenson Peter, Stöckli Linus, Szewczyk Paweł, Uhlir Ludek, Usami Naoto, Vaverka Jakub, Wang Xiao-Dong, Wattieaux Gaëtan, Wieser Martin, Yano Hajime, Yoshikawa Ichiro, Zuppella Paola +223 moreopenaire +11 more sourcesEvaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing
Environmental and Molecular Mutagenesis, EarlyView.Abstract
In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings +15 morewiley +1 more sourceConsensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity
Environmental and Molecular Mutagenesis, EarlyView.Abstract
Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk +14 morewiley +1 more source
