Results 151 to 160 of about 288,189 (359)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl   +14 more
wiley   +1 more source

Radiogenic heating in comets: A computational study from an astrobiological perspective

open access: yesOpen Astronomy
Over the past two decades, interstellar dust and cometary material have been found to include a significant content of organic and biogenic molecules.
Abubacker Thaskeena Angeveettil   +2 more
doaj   +1 more source

Inventory of the volatiles on comet 67P/Churyumov-Gerasimenko from Rosetta/ROSINA

open access: yes, 2015
The ESA Rosetta spacecraft (S/C) is tracking comet 67P/Churyumov-Gerasimenko in close vicinity. This prolonged en- counter enables studying the evolution of the volatile coma composition. Aims. Our work aims at comparing the diversity of the coma of 67P/
L. L. Roy   +17 more
semanticscholar   +1 more source

The gas production rate of periodic comet d'Arrest [PDF]

open access: yes
Comet P/d'Arrest is a potential target for a rendezvous mission to a short period comet. Its light curve is rather peculiar, the comet being active only after perihelion passage. One apparition out of two is easy to observe from the ground.
Ahearn, Michael F.   +2 more
core   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li   +7 more
wiley   +1 more source

The Chicken Egg Genotoxicity Assay (CEGA): Assessing Target Tissue Exposure and Metabolism in the Embryo‐Fetal Chicken Livers

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The Chicken Egg Genotoxicity Assay (CEGA) is an avian egg‐based model that utilizes the livers of developing chicken embryo‐fetuses to assess the ability of chemicals to produce direct DNA damage. The main goal of the study was to evaluate target tissue exposure and metabolism in the CEGA to assess its suitability as a biologically relevant ...
Yax Thakkar   +4 more
wiley   +1 more source

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