Results 151 to 160 of about 225,144 (339)

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Simultaneous Classification and Location of Volcanic Deformation in SAR Interferograms Using a Convolutional Neural Network

Earth and Space Science
With the evolution of interferometric synthetic aperture radar into a tool for active hazard monitoring, new methods are sought to quickly and automatically interpret the large number of interferograms that are created.
M. Gaddes, A. Hooper, F. Albino
doaj   +1 more source

Halley's comet 1985-86: space exploration [PDF]

A coordinated program to explore Halley's comet in 1985 to 86 is proposed. The program employs a variety of observational systems for remote observations and utilizes spacecraft encounters with the comet to obtain in-situ measurements.
Farquhar, R. W., Wooden, W. H., II
core   +1 more source

Bavachalcone targets transferrin receptor and sensitizes gemcitabine to affect bladder cancer progression

iMeta, EarlyView.
Transferrin (Tf) binds extracellular Fe3+ and interacts with transferrin receptor (TFRC) on the cell membrane, leading to endocytosis. Iron is reduced by STEAP3, transported by DMT1 into the cytoplasm, then enters mitochondria to support Fe–S cluster formation, mitochondrial respiration, and ATP production.
Zihao Zhang, Chenyue Yuan, Qintao Ge, Dalong Cao, Wangrui Liu, Meng Xu, Mengfei Wang, Tao Feng, Yue Wang, Shengfeng Zheng, Zhongyuan Wang, Wei zhang, Xi Tian, Wei Huang, Ziqi Chen, Chao Tu, Hailiang Zhang, Guohai Shi, Jialin Meng, Yijun Shen, Ziliang Wang, Dingwei Ye   +21 more
wiley   +1 more source

Polarization of Comet Arend–Roland [PDF]

, 1957
M. K. V. Bappu, S. D. Sinvhal
openalex   +1 more source

Effect of Naringenin on Potassium Bromate–Induced Hepatotoxicity In Vivo: A Dose‐Dependent Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Potassium bromate (PB) is a well‐known additive in the food industry and a byproduct of water treatment. Its long‐term exposure to any form of life exerts mild to severe toxic insults in a dose‐dependent fashion and can even trigger carcinogenesis.
Iftekhar Hassan, Hossam Ebaid, Badar ul Islam, Jameel Al‐Tamimi, Ibrahim M. Alhazza, Altaaf Khan, Ezzat M. Awad   +6 more
wiley   +1 more source

Radio detection of H2O in comet Bradfield (1974b) [PDF]

Results of observations of comet Bradfield using the Haystack telescope are summarized with emphasis on the detection of the 1.35 cm emission line of water in the comet.
Clark, T., Donn, B., Jackson, W. M.
core   +1 more source

Comet Notes [PDF]

Publications of the Astronomical Society of the Pacific, 1943
openaire   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source