Results 181 to 190 of about 70,240 (312)

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Complex versus simple <i>N</i>-nitrosamines: Comprehensive genotoxicity and in silico carcinogenicity assessment toward future testing paradigms. [PDF]

Sci Adv
Sun X, Schuler M, Zhang S, Kostal J, Cheung JR, Kenyon M, Watt E, Dobo K.   +7 more
europepmc   +1 more source

HIV drug resistance and treatment success in the Republic of Congo: Implications for optimized treatment

HIV Medicine, EarlyView.
Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning, Arcy Marcelin Elenga Ike, Johanna Holterhoff, Amira Stockinger, Darrel Ornelle Elion Assiana, Claujens Chastel Mfoutou Mapanguy, Freisnel Hermeland Mouzinga, Carola Horn, Isabelle Suarez, Ferdinand Heyn, Diane Alexia Fila, Hubert Banguissa, Fabien Roch Niama, Donatien Moukassa, Eva Heger, Francine Ntoumi, Clara Lehmann   +16 more
wiley   +1 more source

Optimized genetic tracers for viral mediated neuronal projection mapping. [PDF]

Cell Mol Biol Lett
Dulin JN, Ye L, Grider T, Rizzo A, Rosenzweig ES, Weber J, Ramakrishnan C, Hsueh B, Deisseroth K, Tuszynski MH, Gibbs D, Poplawski GHD.   +11 more
europepmc   +1 more source

Simulation of shell structures of comet Hale-Bopp

, 2003
We present a simulation based on the morphology of inner coma of comet Hale-Bopp(C/1995 O1) which was observed in Shanghai Astronomical Observatory using a 1.56 in telescope in February 1997. The simulation is based on spin stable. Two active regions are
Tao, J, Qian, BC
core  

Analysing Resilience Indicator Traits in Austrian Fleckvieh, Brown Swiss and Holstein‐Friesian Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Recent studies suggest that variations in milk yield during lactation can serve as a metric for assessing individual resilience, with minimum fluctuations reflecting greater resilience in cows. With automatic milking systems, multiple records can be obtained from many cows on a daily basis. Given that animals are continually exposed to a range
M. Agyiri, R. Onzima, A. Costa, B. Fuerst‐Waltl, F. Steininger, C. Egger‐Danner, G. Mészáros, J. Sölkner   +7 more
wiley   +1 more source

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation. [PDF]

Nucleic Acids Res
Li K, Yang F, Wang Y, Shi G, Wang Y, Liu Y, Yan Y, Lei Y, Zhou M, Sun H, Zheng L, Shen B.   +11 more
europepmc   +1 more source

Sodium–glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the COMET trial

Journal of Diabetes Investigation, EarlyView.
Combining oral sodium‐glucose cotransporter 2 inhibitors with reduced intravitreal injections of anti‐vascular endothelial growth factor showed potential efficacy for mild diabetic macular edema. ABSTRACT Aims To investigate the potential of sodium–glucose cotransporter 2 inhibitors (SGLT2i) as a less invasive treatment option for mild diabetic macular
Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Tomoaki Tatsumi, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote   +6 more
wiley   +1 more source

Genotoxicity and gene expression modulation associated with the use of DDVP antiparasitic drugs in aquaculture on <i>Danio rerio</i>. [PDF]

Front Vet Sci
Viralkumar A, Singh LS, Iqbal G, Shrivastava V, Barad RR, Mori K, Kumar S.   +6 more
europepmc   +1 more source

3SD: Rotational symmetry single‐shot denoising in fluorescence microscopy

Journal of Microscopy, EarlyView.
Abstract Image noise is a fundamental problem in fluorescence microscopy analysis, especially in live cell imaging applications where the number of detected photons is limited due to low power of excitation lasers to prevent phototoxicity during extended imaging experiments.
Tijmen H. de Wolf, Pleun Engbers, Justine Perrin, Julie Nonnekens, Ihor Smal   +4 more
wiley   +1 more source