Results 51 to 60 of about 1,716,063 (324)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Topological partition relations to the form omega^*-> (Y)^1_2
, 1993 Theorem: The topological partition relation omega^{*}-> (Y)^{1}_{2} (a) fails for every space Y with |Y| >= 2^c ; (b) holds for Y discrete if and only if |Y|
Comfort W. W. +12 more
core +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Passenger ride quality determined from commercial airline flights [PDF]
, 1975 The University of Virginia ride-quality research program is reviewed. Data from two flight programs, involving seven types of aircraft, are considered in detail.
Jacobson, I. D. +2 more
core +1 more source
Thermal Comfort Assessment in Comfort-Prone Workplaces [PDF]
The Annals of Occupational Hygiene, 2007 This paper's main issue is a strong advocacy in favour of an a priori classification of thermal environments that can be really functional to comfort assessment: Class 1, environments where comfort conditions can be established (comfort-prone environments), and Class 2, environments where this is not practically feasible.
Paolo, Lenzuni, Michele, Del Gaudio
openaire +2 more sources
FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
The influence of randomly allocated group membership when developing student task work and team work capabilities [PDF]
, 2012 This study explores whether randomly assigning group membership enhances the student learning experience. The paper starts with a critical analysis of the approaches to student learning within Higher Education and how these approaches conflict with ...
Mcclelland, Giles Peter
core +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
On the Procedure of Draught Rate Assessment in Indoor Spaces
Applied Sciences, 2020 The objective of the paper is to demonstrate the importance of the unsteady Computational Fluid Dynamics (CFD) simulations and long-term measurements for the reliable assessment of thermal comfort indoors, for proper categorization of the indoor thermal ...
Detelin Markov +9 more
doaj +1 more source