Results 41 to 50 of about 83,966 (308)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Time and Place and Their Function in Ijtihad [PDF]

open access: yesآموزه‌‌های فقه مدني, 2008
This paper studies the function of time and place in ijtihad. Circumstances of time and place in determining the subject of religious precepts has a fundamental function and the subjects of religious commandments are regarded as causes for commands. Thus
Dr. Ali Reza Saberiyan
doaj  

Relation of the General Policies of the System with the Privileged Commandments of the Islamic Ruler in the Constitution of Iran [PDF]

open access: yesپژوهش‌نامه حقوق اسلامی, 2012
The general policies of the Islamic system aim at creating stability and regulation of affairs towards moving to definite objectives in a macro level and also at taking harmonious steps on the part of governmental powers in this direction, hence a novel ...
mohsen esmaeili, hadi tahan nazif
doaj   +1 more source

Thousand to one [PDF]

open access: yes, 1992
Exodus 20:1 ...
Temme, Jon M.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

What are the principles that govern life?

open access: yesCommunicative & Integrative Biology, 2020
We know that living matter must behave in accordance with the universal laws of physics and chemistry. However, these laws are insufficient to explain the specific characteristics of the vital phenomenon and, therefore, we need new principles, intrinsic ...
Jaime Gómez-Márquez
doaj   +1 more source

The Transitioning of Jewish Biomedical Law: Rhetorical and Practical Shifts in Halakhic Discourse on Sex-Change Surgery [PDF]

open access: yes, 2016
This article examines discourse dynamics in Jewish law on sex-change surgery (SCS) and, in general, transitioning between genders. Orthodox medical ethics has moved beyond the abstract condemnation of SCS to the design of practical rules for transsexuals
Hillel Gray
core   +1 more source

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