Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Validating self-reported exclusive breastfeeding in Eswatini using stable isotope techniques. [PDF]
Simelane KS +7 more
europepmc +1 more source
Why human connection is the true metric of research success
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Commentary: Acetaminophen Enhances the Reflective Learning Process
Jonathon McPhetres
doaj +1 more source
Comment on: "Analgesic effects of bilateral ultrasound-guided erector spinae plane block versus patient-controlled intravenous analgesia in correction surgery for idiopathic scoliosis: study protocol for a randomized controlled trial". [PDF]
Sethuraman RM.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Xuefan Zeng,1,* Yiwei Wang2,* 1Chongqing Medical University, Chongqing, People’s Republic of China; 2Tianjin University of Traditional Chinese Medical, Tianjin, People’s Republic of China*These authors contributed equally to this ...
Zeng X, Wang Y
doaj
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Hepatitis C distribution across diverse population groups in the Eastern Mediterranean Region: An umbrella review. [PDF]
Abdolahinia Z +5 more
europepmc +1 more source

