Results 91 to 100 of about 15,126,910 (348)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On the delivery robustness of train timetables with respect to production replanning possibilities [PDF]
, 2012 Measuring timetable robustness is a complex task. Previous efforts have mainly been focused on simulation studies or measurements of time supplements.
Aronsson, Martin +3 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Pricing intelligence as tool for increasing competitiveness of Ukrainian online stores
Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2016 The article defines the concept of e-commerce, analyzes the status and dynamics of e-commerce in Ukraine. The work presents statistical data on the state of Internet commerce in Ukraine, trends for future development.
I.V. Burachek
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
THE LEVEL AND THE DYNAMICS OF THE RETAIL TRADE ACTIVITY IN ROMANIA [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 We are a consumer society. Today the trade has a significant share in the GDP of all countries worldwide. Within the commercial activity a special importance has the retail trade, that commercial link which addresses to the final consumer.
DOBRE-BARON OANA
doaj
Yuridika, 2018 Modernization of judiciary has prompted the reform of courts system in many countries whereby a trend of creating specialized courts is no doubt contributing to the needed justice.
Joel Niyobuhungiro
doaj +1 more source
The credit supply channel of monetary policy: evidence from a FAVAR model with sign restrictions [PDF]
, 2016 We test whether the credit channel of the monetary policy was present in the United States' economy from January 2001 to April 2016. To this end, we use a factor-augmented vector autoregression, and we impose sensible theoretical sign restrictions in our
Holguín, Juan S. +1 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source