Results 181 to 190 of about 1,302,047 (307)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

open access: yesAngewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne   +22 more
wiley   +1 more source

Genetic Diversity in Dutch Sheep Breeds. [PDF]

open access: yesAnim Genet
Hoorneman JN   +4 more
europepmc   +1 more source

Structural adjustment: damages, reparations and pathways to non-recurrence. [PDF]

open access: yesBMJ Glob Health
Hickel J   +3 more
europepmc   +1 more source

Prediction of Properties of Polymer Composite Formulations Using Ensemble Models With Feature Generation

open access: yesJournal of Applied Polymer Science, EarlyView.
This study develops an interpretable machine‐learning framework to predict multiple properties of polymer composites based on composition and processing variables. By combining ensemble models with composition‐based feature generation and SHAP‐based interpretation, the approach reveals composition‐property relationships and supports efficient multi ...
Dong Ryeol Shin, Sung Kwang Lee
wiley   +1 more source

Routes to expanded carrier screening in the UK: The perspectives of professional stakeholders. [PDF]

open access: yesJ Community Genet
Herbrand C   +8 more
europepmc   +1 more source

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

open access: yesAnimal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu   +8 more
wiley   +1 more source

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