Results 71 to 80 of about 116,536 (264)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

open access: yesAdvanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu   +12 more
wiley   +1 more source

Does the implementation of economic policies connected to climate change depend on monetary policy mandates and financial stability governance structures?

open access: yesHeliyon
The objective of the proposed research study is to examine how the economic policy mandates and governance frameworks of central banks affect the implementation of climate-related economic measures.
Liu Cheng, Chang Wu
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

open access: yesAdvanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai   +7 more
wiley   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

open access: yesAdvanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu   +11 more
wiley   +1 more source

Assessing the economic impact of climate risk on green and low-carbon transformation

open access: yesFrontiers in Environmental Science
IntroductionLimate risk poses significant challenges to sustainable development, particularly in the context of transitioning to green and low-carbon economies. The complexity of these interactions makes it difficult to devise strategies that effectively
Chen Qin, Hongli Lou, Li Li
doaj   +1 more source

Peć's Commercial-industrial Bank [PDF]

open access: yesBaština, 2014
In order to protect Serbian civic class from the decline, in Peć 1907 was founded the Fund of 'The Holy Mother of God of Miraculous Icon Pećska'. By liberation from the Osman's authority and becoming the part of the Kingdom of Montenegro, which fully ...
Becić Ivan M.
doaj  

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