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Measurement of Centanafadine Concentrations in a Pharmacokinetic Trial: Comparison of Traditional Venipuncture Versus Blood Microsampling [PDF]

Clinical and Translational Science
In clinical pharmacology trials, pharmacokinetic samples are typically collected via venipuncture by trained staff. However, recent advances in blood collection devices have enabled participant self‐collection of samples.
Sharin E. Roth, Lucas Westcott‐Baker, Yanlin Wang, Chris Chung   +3 more
doaj   +2 more sources

Feasibility of a Noninterventional Decentralized Clinical Trial Model in Adults with Major Depressive Disorder

Journal of Scientific Innovation in Medicine, 2021
Objective:Adding to existing challenges in conducting clinical trials, COVID-19 has indefinitely affected modern clinical research. Decentralized clinical trials, using telemedicine and digital technology, may prove critical to the future of clinical ...
J. Corey Fowler, Taisa Skubiak, Kirsten Engelhardt, Benjamin Furst, Sophia Zhao, Margaretta Nyilas, Debbie Profit, William Carson   +7 more
doaj   +1 more source

Development of process analytical tools for rapid monitoring of live virus vaccines in manufacturing

Scientific Reports, 2022
In the development of end-to-end large-scale live virus vaccine (LVV) manufacturing, process analytical technology (PAT) tools enable timely monitoring of critical process parameters (CPP) and significantly guide process development and characterization.
Sijia Yi, Reilly McCracken, Joseph Davide, Daniel Ryan Salovich, Travis Whitmer, Aditya Bhat, Josef Vlasak, Sha Ha, Darrell Sehlin, Joseph Califano, Kristin Ploeger, Malini Mukherjee   +11 more
doaj   +1 more source

Characterization of activity behavior using a digital medicine system and comparison to medication ingestion in patients with serious mental illness

npj Digital Medicine, 2021
Activity patterns can be important indicators in patients with serious mental illness. Here, we utilized an accelerometer and electrocardiogram incorporated within a digital medicine system, which also provides objective medication ingestion records, to ...
Jeffrey M. Cochran, Zahra Heidary, Jonathan Knights   +2 more
doaj   +1 more source

Preferentially oriented growth of diamond films on silicon with nickel interlayer

SN Applied Sciences, 2022
A multistep deposition technique is developed to produce highly oriented diamond films by hot filament chemical vapor deposition (HFCVD) on Si (111) substrates. The orientation is produced by use of a thin, 5–20 nm, Ni interlayer.
Anupam K.C., Anwar Siddique, Jonathan Anderson, Rony Saha, Chhabindra Gautam, Anival Ayala, Chris Engdahl, Mark W. Holtz, Edwin L. Piner   +8 more
doaj   +1 more source

Flow virometry for process monitoring of live virus vaccines-lessons learned from ERVEBO

Scientific Reports, 2021
Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or damaged virions with reduced potency is rate-limited by release potency assays with long ...
Geoffri Ricci, Kevin Minsker, Austin Kapish, James Osborn, Sha Ha, Joseph Davide, Joseph P. Califano, Darrell Sehlin, Richard R. Rustandi, Lawrence W. Dick, Josef Vlasak, Timothy D. Culp, Andreas Baudy, Edward Bell, Malini Mukherjee   +14 more
doaj   +1 more source

Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

Scientific Reports, 2023
Decreased estrogens during menopause are associated with increased risk of anxiety, depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by ovariectomy, combined with a high-fat diet (HFD), increases anxiety and adiposity ...
Kalpana D. Acharya, Madeline Graham, Harshini Raman, Abigail E. R. Parakoyi, Alexis Corcoran, Merzu Belete, Bharath Ramaswamy, Shashikant Koul, Ishneet Sachar, Kevin Derendorf, Jeremy B. Wilmer, Srikanth Gottipati, Marc J. Tetel   +12 more
doaj   +1 more source

Designing and explaining a model for creation and development of knowledge-based cooperative companies with a mixed qualitative-quantitative approach [PDF]

Journal of Applied Research on Industrial Engineering, 2022
The present research aims to design a model for the creation and development of knowledge-based cooperative companies in Semnan province by a mixed qualitative-quantitative approach.
Younos Vakil Alroaia, Samira Nazari Ghazvini   +1 more
doaj   +1 more source

Effects of tolvaptan discontinuation in patients with autosomal dominant polycystic kidney disease: a post hoc pooled analysis

BMC Nephrology, 2023
Background Tolvaptan slows kidney function decline in patients with autosomal dominant polycystic kidney disease (ADPKD) who are at risk of rapid progression.
Michael Lioudis, Xiaolei Zhou, Eric Davenport, Sasikiran Nunna, Holly B. Krasa, Dorothee Oberdhan, Ancilla W. Fernandes   +6 more
doaj   +1 more source

Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters

Clinical and Translational Science, 2021
Tolvaptan (TLV) was US Food and Drug Administration (FDA)‐approved for the indication to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease in 2018.
Susan E. Shoaf, Patricia Bricmont, Jennifer Repella Gordon   +2 more
doaj   +1 more source