Results 141 to 150 of about 1,232,124 (326)
Cancer in sub-Saharan Africa: a Lancet Oncology Commission.
The Lancet Oncology, 2022 W. Ngwa, B. W. Addai, I. Adewole, V. Ainsworth, James Alaro, O. Alatise, Z. Ali, B. Anderson, R. Anorlu, S. Avery, P. Barango, N. Bih, C. Booth, O. Brawley, J. Dangou, L. Denny, J. Dent, S. Elmore, A. Elzawawy, Diane Gashumba, J. Geel, K. Graef, S. Gupta, S. Gueye, N. Hammad, L. Hessissen, André M. Ilbawi, Joyce Kambugu, Z. Kozlakidis, S. Manga, Lize Maree, S. Mohammed, S. Msadabwe, M. Mutebi, Annet Nakaganda, N. Ndlovu, Kingsley Ndoh, J. Ndumbalo, M. Ngoma, T. Ngoma, Christian Ntizimira, T. Rebbeck, L. Renner, A. Romanoff, F. Rubagumya, S. Sayed, S. Sud, H. Simonds, R. Sullivan, W. Swanson, V. Vanderpuye, Boateng Wiafe, David Kerr +52 moresemanticscholar +1 more sourceATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs +11 morewiley +1 more sourceThe Lancet Commission on prostate cancer: planning for the surge in cases
The LancetN. D. James, Ian F. Tannock, J. N'Dow, Felix Y Feng, Silke Gillessen, Syed Adnan Ali, Blanca Trujillo, B. Al-Lazikani, Gerhardt Attard, F. Bray, Eva M Compérat, R. Eeles, O. Fatiregun, E. Grist, S. Halabi, Á. Haran, D. Herchenhorn, Michael Hofman, Mohamed Jalloh, Stacy Loeb, A. Macnair, Brandon A. Mahal, L. Mendes, M. Moghul, Caroline M. Moore, A. Morgans, M. Morris, Declan G Murphy, V. Murthy, Paul L. Nguyen, A. Padhani, Charles T A Parker, H. Rush, M. Sculpher, H. Soule, M. Sydes, D. Tilki, N. Tunariu, P. Villanti, Li-Ping Xie +39 moresemanticscholar +1 more sourceA subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli +3 morewiley +1 more sourceCommissioning of Bunch Compressor to Compress Space Charge-Dominated Electron Beams for THz Applications [PDF]
Anusorn Lueangaramwong, Ekkachai Kongmon, Xiangkun Li, Prach Boonpornprasert, Georgi Georgiev, M. Krasilnikov, Zakaria Aboulbanine, Gowri Adhikari, Namra Aftab, Matthias Groß, Raffael Niemczyk, A. Oppelt, Houjun Qian, C. Richard, G. Vashchenko, Tobias Weilbach, F. Stephan +16 moreopenalex +1 more sourceOur future: a Lancet commission on adolescent health and wellbeing
The Lancet, 2016 G. Patton, S. Sawyer, J. Santelli, D. Ross, R. Afifi, N. Allen, M. Arora, P. Azzopardi, W. Baldwin, C. Bonell, R. Kakuma, Elissa C Kennedy, Jaqueline Mahon, T. Mcgovern, A. Mokdad, V. Patel, S. Petroni, N. Reavley, Kikelomo Taiwo, Jane Waldfogel, Dakshitha Wickremarathne, C. Barroso, Z. Bhutta, A. Fatusi, A. Mattoo, J. Diers, Jing Fang, J. Ferguson, F. Ssewamala, R. Viner +29 moresemanticscholar +1 more sourceA future for the world's children? A WHO–UNICEF–Lancet Commission
The Lancet, 2020 H. Clark, A. Coll-Seck, Anshu Banerjee, S. Peterson, Sarah L Dalglish, S. Ameratunga, D. Balabanova, M. Bhan, Z. Bhutta, J. Borrazzo, M. Claeson, T. Doherty, F. El-Jardali, A. George, Angela Gichaga, Lu Gram, D. Hipgrave, A. Kwamie, Q. Meng, R. Mercer, S. Narain, J. Nsungwa-Sabiiti, A. Olumide, D. Osrin, T. Powell-Jackson, K. Rasanathan, Imran Rasul, Papaarangi Reid, Jennifer Requejo, S. Rohde, N. Rollins, M. Romedenne, H. Sachdev, R. Saleh, Y. Shawar, J. Shiffman, J. Simon, P. Sly, K. Stenberg, M. Tomlinson, R. Ved, A. Costello +41 moresemanticscholar +1 more sourceThe Lancet Nigeria Commission: investing in health and the future of the nation
The Lancet, 2022 I. Abubakar, Sarah L Dalglish, B. Angell, O. Sanuade, S. Abimbola, A. Adamu, Ifedayo M. O. Adetifa, T. Colbourn, A. Ogunlesi, O. Onwujekwe, E. Owoaje, I. Okeke, A. Adeyemo, Gambo Aliyu, M. Aliyu, S. Aliyu, E. Ameh, B. Archibong, A. Ezeh, M. Gadanya, C. Ihekweazu, Vivianne Ihekweazu, Z. Iliyasu, Aminatu Kwaku Chiroma, D. Mabayoje, Mohammed Nasir Sambo, S. Obaro, A. Yinka-Ogunleye, F. Okonofua, T. Oni, Oluchukwu Onyimadu, M. Pate, B. Salako, F. Shuaib, F. Tsiga-Ahmed, Fatima H Zanna +35 moresemanticscholar +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more source
