Results 151 to 160 of about 1,232,124 (326)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Osteoarthritis in 2020 and beyond: a Lancet Commission

The Lancet, 2020
D. Hunter, L. March, M. Chew
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

LGBTIQA+ Inclusion in Aged Care: Perspectives From Providers and Community Stakeholders. [PDF]

Australas J Ageing
Tissot D, Karacsony S, Andrews S, James R.   +3 more
europepmc   +1 more source

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness.

Lancet psychiatry, 2019
J. Firth, N. Siddiqi, A. Koyanagi, D. Siskind, S. Rosenbaum, C. Galletly, S. Allan, Constanza Caneo, R. Carney, A. Carvalho, M. Chatterton, C. Correll, J. Curtis, F. Gaughran, A. Heald, E. Hoare, S. Jackson, S. Kisely, K. Lovell, M. Maj, P. McGorry, C. Mihalopoulos, Hannah Myles, B. O’Donoghue, T. Pillinger, J. Sarris, F. Schuch, D. Shiers, Lee Smith, M. Solmi, S. Suetani, Johanna Taylor, S. Teasdale, G. Thornicroft, J. Torous, T. Usherwood, D. Vancampfort, N. Veronese, P. Ward, A. Yung, E. Killackey, B. Stubbs   +41 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Revitalizing poly(urea)s via disulfide reconfiguration. [PDF]

Sci Adv
Zong Z, Qu DH, Tian H, Zhang Q.
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Requests for Commission reports [7], 1991-07-11/1991-07-22

, 2021
Unknown
openalex   +2 more sources

The politics of Aboriginal title in British Columbia: from the Referendum to the Truth and Reconciliation Commission

, 2017
David Rossiter, Patricia Burke Wood
openalex   +1 more source